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師資 faculty

神經資訊造影暨工程組

 

郭博昭 教授
M.D, Ph.D.

陽明大學 腦科學研究所 專任教授
中央大學 生醫講座教授
中央大學 生醫科學與工程學系 合聘教授
智慧電子研發成果橋接計畫 顧問

Tel: (02)28267058
Fax: (02)28273123

E-mail : tbjkuo@ym.edu.tw

 

研究室網頁

 

 

主要學歷

1993/09-1996/06

博士 陽明大學 藥理學研究所
畢業論文:動脈壓訊號頻譜成份之生理與藥理分析。
1986/09-1993/06 醫學士 陽明大學 醫學系

 

現職及與專長相關之經歷

現職

2006/02- 國立陽明大學 腦科學研究所 專任教授
2014/08- 國立中央大學 生醫講座教授
2015/08- 國立中央大學 生醫科學與工程學系 合聘教授
2016/07-
智慧電子研發成果橋接計畫 顧問

經歷

2016/03-2017/01     國立陽明大學 教師會 理事長
2015/12-2017/01     國立陽明大學 腦科學研究所 所長
2015/12-2017/01     國立陽明大學 神經科學研究所 所長
2015/11-2016/07     國立陽明大學 副教務長
2012/01-2015/12     智慧電子國家型科技計畫 醫療電子分項 召集人
2014/08-2015/07     國立中央大學 生醫理工學院 副院長
2014/08-2015/07     國立中央大學 跨領域轉譯醫學研究所 所長
2014/08-2015/07     國立中央大學 生醫科學與工程學系 籌備主任
2010/04-2015/01     行政院衛生署 遠距健康照護服務發展計畫專案 主任
2011/03-2013/07     臺北市立聯合醫院 教學研究部研究發展組 主任
2006/02-2012/07     國立陽明大學 腦科學研究所 所長
2007/08-2010/07     國立陽明大學 研發處 研發長
2007/01-2008/07     國立陽明大學 腦科學研究中心 主任
2006/02-2008/07     臺灣聯合大學系統 腦科學中心 主任
2006/02-2007/07     國立陽明大學 育成中心 主任
2001/01-2006/01     慈濟大學 神經科學研究所 所長
2000/02-2006/01     慈濟大學 神經科學研究所 教授
1999/08-2001/03     慈濟醫院 神經內科 住院醫師
1999/08-2000/01     慈濟醫學暨人文社會學院 神經科學研究所 副教授
1996/08-1999/07     國立陽明大學 課外活動輔導組 主任
1996/08-1999/07     國立陽明大學 醫學系藥理學科 副教授

 

專長

研究專長: 神經科學、電腦科學、生理學、資訊學、轉譯醫學、醫療儀器等
教學專長: 生理學、神經科學、睡眠醫學、自主神經學、論文寫作實務、微電腦於生物醫學的的應用等



重要獎項及榮譽

中華民國十大傑出青年,國際青年商會中華民國總會,2004
全國社會優秀青年代表,中國青年救國團,2001
李國鼎青年研究獎,ACM 台北/台灣分會與中華民國資訊學會,2000
王世濬院士青年研究獎,中華民國基礎神經科學學會,1999



社會服務

研究計畫審查委員 國科會神經學門、運動學門、心理學門、工程學門、生理學門台北市立聯合醫院、陽明附設醫院
期刊審查委員 擔任慈濟醫學雜誌、The Chinese Journal of Physiology、Clinical Science、Circulation、American Journal of Physiology、American Journal of Cardiology等審查委員
期刊編輯委員 Clinical Science、Advances in Adaptive Data Analysis期刊編輯委員
顧問 工研院醫療器材中心

 

研究成果 (* : Corresponding Author; : Co-first Author)

1.  Li, J. Y., Kuo, T. B. J., Yang, C. C. H.* (2016) Aged rats show the dominant modulation on lower frequency of hippocampal theta rhythm during running. Experimental Gerontology 83:63-70

2.  Kuo, T. B. J. , Lai, C. T. , Chen, C. Y. , Yang, Y. C., Yang, C. C. H.* (2016) The high-frequency component of heart rate variability during extended wakefulness is closely associated with the depth of the ensuing sleep in C57BL6 mice. Neuroscience 330: 257-66

3.  Lin, Y. C., Lin, Y. H., Lo, M Z., Peng, C. K., Huang, N. E., Yang, C. C. H., Kuo, T. B. J.* (2016) Novel application of multi dynamic trend analysis as a sensitive tool for detecting the effects of aging and congestive heart failure on heart rate variability. Chaos 26:023109

4.  Hong C. H. , Kuo, T. B. J. , Huang B. C., Lin Y. C., Kuo K. L., Chern C. M., Yang, C. C. H.* (2016) Cold exposure can induce an exaggerated early-morning blood pressure surge in young prehypertensives. PLoS One.11(2):e0150136

5.  Huang W. L., Liao S. C., Kuo, T. B. J., Chang, L .R., Chen, Z. T., Chen, I. M., Yang, C. C. H.* (2015) The effects of antidepressants and quetiapine on heart rate variability. Pharmacopsychiatry [Epub ahead of print]

6.  Kuo, T. B. J. , Chen C. Y. , Hsu, Y. C., Yang, C. C. H.* (2016) EEG beta power and heart rate variability describe the association between cortical and autonomic arousal across sleep. Autonomic Neuroscience: basic and clinical 194:32-7

7.  Kuo, T. B. J. , Li, J. Y. , Kuo, H. K., Chern, C. M., Yang, C. C. H.* (2016) Differential changes and interactions of autonomic functioning and sleep architecture before and after 50 years of age. Age 38:5

8.  Tsai, H. J. , Kuo, T. B. J., Lin, Y. C. , Yang, C. C. H.* (2015) The association between prolonged sleep onset latency and heart rate dynamics among young sleep-onset insomniacs and good sleepers. Psychiatry Research 230:892-898

9.  Lai, C. T., Chen, C. Y., Kuo, T. B. J., Chern, C. H., Yang, C. C. H.* (2015) Sympathetichyperactivity, sleep fragmentation and wake-related blood pressure surge during late-light sleep in spontaneously hypertensive rats. American Journal of Hypertension 29:590-7

10.  Wang, Y. B., Kuo, T. B. J., Lai C.T., Yang, C. C. H.* (2015) Effects of breathing frequency on the heart rate deceleration capacity and heart rate acceleration capacity. European Journal of Applied Physiology 115:2415-2420

11.  Huang W. L., Hwang B. T., Lai C. T., Li J. Y., Kuo, T. B. J., Yang, C. C. H.* (2015) Is heart rate variability related to season of birth? Clinical Cardiology 38:407-412

12.  Lin Y. H., Lin Y. C., Lee Y. H., Lin P. H., Lin S. H., Chang L. R., Tseng H. W., Yen L. Y., Yang, C. C. H., Kuo, T. B. J.* (2015) Time distortion associated with smartphone addiction: identifying smartphone addiction via a mobile application (App) Journal of Psychiatric Research 65:139-145

13.  Tsai, H. J., Kuo, T. B. J., Lee, G. S., Yang, C. C. H.* (2015) Efficacy of paced breathing for insomnia: enhances vagal activity and improves sleep quality. Psychophysiology 52:388-396

14.  Wang, Y. B., Kuo, T. B. J., Yang, C. C. H.* (2014) A possible explanation for the effects of respiration on heart rate and blood pressure asymmetry. International Journal of Cardiology 174:805-807

15.  Kuo, T. B. J., Hong, C. H. , Hsieh, I. T., Lee, G. S., Yang, C. C. H.* (2014) Effects of cold exposure on autonomic changes during the last REM sleep transition and morning blood pressure surge in humans. Sleep Medicine 15:986-997

16.  Li, J. Y., Kuo, T. B. J., Yen, J. C., Tsai, S. C., Yang, C. C. H.* (2014) Voluntary and involuntary running in the rat show different patterns of theta rhythm, physical activity and heart rate. Journal of Neurophysiology 111:2061-2070

17.  Wang, Y. P., Kuo, T. B. J., Yang, C. C. H.* (2014) Reply to Hejjel. Journal of Applied Physiology 116:710 (Letter)

18.  Kuo, T. B. J., Chen, C. Y., Wang, Y. P., Lane Y. Y., Mak, K. H., Yang, C. C. H.* (2014) The role of autonomic and baroreceptor reflex control in blood pressure dipping and non-dipping in rats. Journal of Hypertension 32:806-816

19.  Chiang, J. K., Kuo, T. B. J., Fu, C. H., Koo, M.* (2013) Predicting 7-day survival using heart rate variability in hospice patients with non-lung cancers. Plos One 23:e69482

20.  Kuo, T. B. J., Li, J. Y., Lai, C. T., Huang, Y. C., Hsu, Y. C., Yang, C. C. H.* (2013) Effect of bedding system selected by manual muscle testing on sleep-related cardiovascular functions. Biomed Research International http://dx.doi.org/10.1155/2013/937986 (SCI)

21.  Wang, Y. P., Kuo, T. B. J., Lai, C. T., Chu, J. W., Yang, C. C. H.* (2013) Effects of respiratory time ratio on heart rate variability and spontaneous baroreflex sensitivity. Journal of Applied Physiology 115:1648-1655 (SCI)

22.  Chen, C. Y., Kuo, T. B. J., †, Hsieh, I. T., Yang, C. C. H.* (2013) Electrical stimulation of the rostral ventrolateral medulla promotes wakefulness in rats. Sleep Medicine 14:1076-1084 (SCI)

23.  Lin, Y. H., Ho, Y. C., Lin, S. H., Yeh, Y. H., Liu, C. Y., Kuo, T. B. J., Yang, C. C. H., Yang, A. C.* (2013) On-call duty effects on sleep-state physiological stability in male medical interns. Plos One 8:e65072 (SCI)

24.  Huang, S. S., Cheng, H., Tang, C. M., Nien, M. Y., Huang, Y. S., Lee, I. H., Yin, J. H., Kuo, T. B. J., Yang, C. C. H., Tsai, S. K.*,Yang, D.I* (2013) Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Experimental Neurology 248:680-688 (SCI)

25.  Liu, K. D., Shan, D. I., Kuo, T. B. J., Yang, C. C. H.* (2013) The effects of bilateral stimulation of the subthalamic nucleus on heart rate variability in patients with Parkinson’s disease. Journal of Neurology 260:1714-1723 (SCI)

26.  Huang, W. L., Chang, L. R., Kuo, T. B. J., Lin, Y. H., Chen, Y. Z., Yang, C. C. H.* (2013) Gender differences in personality and heart rate variability. Psychiatry Research 209: 652-657 (SCI)

27.  Lin, Y. C., Chen, C. Y., Lin, S. H., Liu, C. H., Weng, W. H., Kuo, T. B. J. and Yang, C. C. H.* (2013) Gender differences in cardiac autonomic modulation during medical internship. Psychophysiology 50:521-527 (SCI)

28.  Chang, H. A., Chang, C. C., Tzeng, N. S., Kuo, T. B. J., Lu, R. B. and Huang, S. Y. (2012) Decreased cardiac vagal control in drug-naïve patients with posttraumatic stress disorder. Psychiatry Investigation 19:192-200 (SCI)

29.  Wang, T. S.,, Huang, W. L., Kuo, T. B. J., Lee, G. S. and Yang, C. C. H.* (2012) Inattentive and hyperactive preschool-age boys have lower sympathetic and higher parasympathetic activity. Journal of Physiological Sciences 36:87-94 (SCI) NSC 100-2627-B-010-002.

30.  Kuo, T. B. J., Lai, C. T., Chen, C. Y., Lee, G. S. and Yang, C. C. H.* (2012) Unstable sleep and higher sympathetic activity during late sleep periods of rats: implication for late sleep-related higher cardiovascular events. Journal of Sleep Research 22:108-118 (SCI)

31.  Huang, W. L., Chang, L. R., Kuo, T. B. J., Lin, Y. H., Chen, Y. Z. and Yang, C. C. H.* (2012) Impact of antipsychotics and anticholinergics on autonomic modulation in patients with schizophrenia. The Journal of Clinical Psychopharmacology 33:170-177 (SCI) NSC 99-2314-B-010-014.

32.  Hsieh, I. T., Yang, C. C. H., Chen, C. Y., Lee, G. S., Kao, F. J., Kuo K. L. and Kuo, T. B. J.* (2012) Uninterrupted wireless long-term recording of sleep patterns and autonomic function in freely moving rats. Journal of Medical and Biological Engineering 33:79-86 (SCI)

33.  Chen H. C., Yang, C. C. H., Kuo, T. B. J., Su, T. P. and Chou, P.* (2012) Cardiac vagal control and theoretical models of co-occurring depression and anxiety: A cross-sectional psychophysiological study of community elderly. BMC Psychiatry 12:93 (SCI)

34.  Wang, Y. P., Kuo, T. B. J., Lai, C. T., Lee, G. S. and Yang, C. C. H.* (2012) Effects of breating frequency on baroreflex effectiveness index and spontaneous baroreflex sensitivity derived by sequence analysis. Journal of Hypertension 30: 2151-2158 (SCI)

35.  Kuo, T. B. J., Chen, C. Y., Lai, C. T., Chuan, T. Y., Wu, W. Y., Tsai, S. C. and Yang, C. C. H.* (2012) Sleep disturbance among spontaneously hypertensive rats is mediated by an α1-adrenergic mechanism. American Journal of Hypertension 25:1110-1117 (SCI) NSC 96-2628-B-010-029.

36.  Li, J. Y., Kuo, T. B. J., Hsieh, I. T. and Yang, C. C. H.* (2012). Changes in hippocampal theta rhythm and their correlations with speed during different phases of voluntary wheel running in rats. Neuroscience 213:54-61 (SCI) NSC 100-2314-B-010-020-MY2.

37.  Chua, Y. C.*, Yang, C. C. H., Lin, H. T., Chen, P. T., Chang, K. Y., Yang, S. C. and Kuo, T. B. J. (2012) Neonatal nociception elevated baseline blood pressure and attenuated cardiovascular responsiveness to noxious stress in adult rats. International Journal of Developmental Neuroscience 30:421-426 (SCI)

38.  Huang, S. S., Su, H. H., Kuo, T. B. J., Chen, C. Y., Lan, Y. Y., Liu, B. Y., Young, D. I., Tsai, S. C. and Yang, C. C. H.* (2012) Suppressing cardiac vagal modulation and changing sleep patterns in rats after chronic ischemic stroke injury. Autonomic Neuroscience-Basic and Clinical 169:116-123

39.  Wang, Y. C., Chen, C. Y., Kuo, T. B. J., Lai, C. J. and Yang, C. C. H.,* (2012) The influences of antipsychotic agents on the heart rate variability in male WKY rats: implications for cardiovascular safety. Neuropsychobiology 65:216-226

40.  Kuo, T. B. J., Chen, C. Y., Hsu, Y. C. and Yang, C. C. H.* (2012) Performance of the frequency domain indices with respect to sleep staging. Clinical Neurophysiology 123:1338-1345

41.  Huang, W. L., Lin, Y. H., Kuo, T. B. J., Chang, L. R., Chen, Y. Z. and Yang, C. C. H.* (2012) Methadone-mediated autonomic functioning of male patients with heroin dependence: the influence of borderline personality pattern. PLoS ONE 7:e37464

42.  Chung, M. H., Kuo, T. B. J., Hsu, N., Chu, H., Chou, K. R. and Yang, C. C. H.* (2012) Recovery after three-shift work: relation to sleep-related cardiac neuronal regulation in nurses. Industrial Health 50:24-30

43.  Chang, L. R., Lin, Y. H., Kuo, T. B. J., Ho, Y. C., Chen, S. H., Wu Chang, H. C., Liu, C. M. and Yang, C. C. H.* (2012) Cardiac autonomic modulation during methadone therapy among heroin users: a pilot study. Progress in Neuro-Psychopharmacology & Biological Psychiatry 37:188-193

44.  Chen, P. L., Kuo, T. B. J., and Yang, C. C. H.* (2012) Parasympathetic activity correlates with early outcome in patients with large artery atherosclerotic stroke. Journal of the Neurological Sciences 314:57-61

45.  Lin, Y. H., Kuo, T. B. J., Ho, Y. C., Lin, S. H., Liu, C. Y. and Yang, C. C. H.* (2012) Physiological and psychological impacts on male medical interns of on-call duty. Stress 15:21-30

46.  Chang, L. R., Lin, Y. H., Kuo, T. B. J., Wu Chang, H. C., Liu, C. M., Liu, C. C., Hwu, H. G., and Yang, C. C. H.* (2011) Autonomic Modulation and Health-related Quality of Life among Schizophrenic Patients Treated with Non-intensive Case Management. PLoS ONE 6:e26378

47.  Chung, M. H., Kuo, T. B. J., Hsu, N., Chuo, K. R., Chu, H. and Yang, C. C. H.* (2011) Comparison of sleep-related cardiac autonomic function between rotating-shift and permanent night-shift workers. Industrial Health 49:589-596

48.  Kuo, T. B. J., Li, J. Y., Chen, C. Y., and Yang, C. C. H.* (2011) Changes in hippocampal theta activity during initiation and maintenance of running in the rat. Neuroscience 194:27-35

49.  Chen, S. Y., Yang, C. C. H., Kuo, T. B. J. and Harnod T.* (2011) Association of heart rate variability with clinical outcome in parkinsonian patients after subthalamic deep brain stimulation: A retrospective cohort study. Journal of the Formosan Medical Association 110:593-599

50.  Huang, Y. M., Yang, C. C. H., Lai, C. J. and Kuo, T. B. J.* (2011) The influence of autonomic interventions on the sleep-wake related changes in gastric myoelectrical activity in rats. Neurogastroenterology & Motility 23:560-e208

51.  Kung, Y. Y., Yang, C. C. H., Chiu, J. H. and Kuo, T. B. J.* (2011) The relationship of subjective sleep quality and cardiac autonomic nervous system in postmenopausal women with insomnia under auricular acupressure. Menopause 18: 638-645

52.  Chiang, J. K., Fu, C. H., Kuo, T. B. J. and Koo, M.* (2011) Association between Frequency Domain Heart Rate Variability and Unplanned Readmission to Hospital in Geriatric Patients. BMC Public Health 11:137

53.  Kuo, T. B. J., Yuan, Z. F., Lin, Y. S., Lin, Y. N., Li, W. S., Yang, C. C. H. and Lai, C. J.* (2011) Reactive oxygen species are the cause of the enhanced cardiorespiratory response induced by intermittent hypoxia in conscious rats. Respiratory Physiology & Neurobiology 175:70-79

54.  Chen, C. Y., Yang, C. C. H., Lin, Y. Y. and Kuo, T. B. J.* (2011) Locomotion-induced hippocampal theta is independent of visual information in rats during movement through a pipe. Behavioural Brain Research 216:699-704

55.  Chen, W. L., Tsai, T. H., Yang, C. C. H. and Kuo, T. B. J.* (2010) Effects of ephedra on autonomic nervous modulation in healthy young adults. Journal of Ethnopharmacology 130:563-568

56.  Chen, W. L., Tsai, T. H., Yang, C. C. H. and Kuo, T. B. J.* (2010) Acute effects of ephedra on autonomic nervous modulation in healthy young adults. Clinical Pharmacology and Therapeutics 88:39-44

57.  Kuo, T. B. J., Li, J. Y., Hsieh, S. S. Y., Chen, J. J., Tsai, C. Y., and Yang, C. C. H.* (2010) Effect of aging on treadmill exercise induced theta power in the rat. Age 32:297-308

58.  Kuo, T. B. J., Lai, C. T., Hsu, F. C., Tseng, Y. J., Li, J. Y., Shieh, K. R., Tsai, S. C., and Yang, C. C. H.* (2010) Cardiac neural regulation oscillates with the estrous cycle in freely moving female rats: the role of endogenous estrogens. Endocrinology 151:2613-2621

59.  Lai, I. C., Yang, C. C. H., Kuo, T. B. J., and Shieh, K. R.* (2010) Transcranial magnetic stimulation for auditory hallucination in severe schizophrenia: partial efficacy and acute elevation of sympathetic modulation. Psychiatry and Clinical Neurosciences 64:333-335

60.  Chiang, J. K., Koo, M., Kuo, T. B. J., and Fu, C. H.* (2010) Association between cardiovascular autonomic functions and time to death in patients with terminal hepatocellular carcinoma. Journal of Pain and Symptom Management 39:673-679

61.  Hsin, Y., Yang, C. C. H., Kuo, T. B. J., and Harnod, T.* (2010) Effects of chronic epilepsy on heart rate variability. Neural Regeneration Research 5:156-160

62.  Huang, Y. M., Yang, C. C. H., Lai, C. J., and Kuo, T. B. J.* (2010) Involvement of sympathetic function in the sleep-related change of gastric myoelectrical activity in rats. Journal of Sleep Research 19:192-200

63.  Chen, H. C., Yang, C. C. H., Kuo, T. B. J., Su, T. P., and Chou, P.* (2010) Gender differences in the relationship between depression and cardiac autonomic function among community elderly. International Journal of Geriatric Psychiatry 25:314-322

64.  Huang, H. H., Tseng, C. Y., Fan, J. S., Yen, D. H., Kao, W. F., Chang, S. C., Kuo, T. B. J., Huang, C. I., and Lee, C. H. (2010) Alternations of heart rate variability at lower altitude in the predication of trekkers with acute mountain sickness at high   altitude. Clinical Journal of Sport Medicine 20:58-63

65.  Tsai, P. Y., Hu, W. C., Kuo, T. B. J., and Shyu, L. Y. (2009) A portable device for real time drowsiness detection using novel active dry electrode system. Conference Proceedings- IEEE Engineering in Medicine and Biology Society 1:3775-3778

66.  Sun, T. B.*, Kuo, T. B. J., and Yang, C. C. H. (2009) Power spectral analysis of perfusion signals on free radial forearm flap transplantation in humans. Microsurgery 29:636-643

67.  Sun, T. B.*, Kuo, T. B. J., and Yang, C. C. H. (2009) Nonparallel cutaneous microcirculatory responses to pharmacologic alterations of systemic arterial pressure in rats. Microsurgery 29:319-325

68. Chung, M. H., Kuo, T. B. J., Hsu, N., Chu, H., Chou, K. R., and Yang, C. C. H.* (2009) Sleep and autonomic nervous system changes - enhanced cardiac sympathetic modulations during sleep in permanent night shift nurses. Scandinavian Journal of Work Environment & Health 35:180-187

69.  Kuo, T. B. J., and Yang, C. C. H.* (2009) Frequency domain analysis of electrooculogram and its correlation with cardiac sympathetic function. Experimental Neurology 217:38-45

70.  Kuo, T. B. J., Yang, C. C. H.*, and Huang, N. E. (2009) Quantification of respiratory sinus arrhythmia using Hilbert-Huang transform. Advances in Adaptive Data Analysis 1:295-307

71.  Chen, C. J., Kuo, T. B. J., Tseng, Y. J., and Yang, C. C. H.* (2009) Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction. Clinical Neurophysiology 120:348-352

72.  Harnod, T., Yang, C. C. H., Hsin, Y. L., Wang, P. J., Shieh, K. R., and Kuo, T. B. J.* (2009) Heart rate variability in patients with frontal lobe epilepsy. Seizure: European Journal of Epilepsy 18:21-25

73.  Chung, M. H., Chang, F. M., Yang, C. C. H., Kuo, T. B. J., and Hsu, N.* (2009) Sleep quality and morningness-eveningness of shift nurses. Journal of Clinical Nursing 18:279-284

74.  Wang, Y. C., Yang, C. C. H., Bai, Y. M., and Kuo, T. B. J.* (2008) Heart rate variability in schizophrenic patients switched from typical antipsychotic agents to amisulpride and olanzapine: 3-month follow-up. Neuropsychobiology 57:200-205

75.  Yang, C. C. H., Yeh, I. T., Lai, H. Y., Chen, H. I., and Kuo, T. B. J.* (2008) Dynamic effects of respiration on aortic blood flow and its autonomic control in rats. Clinical and Experimental Pharmacology and Physiology 35:1294-1300

76.  Ko, J. H., Kuo, T. B. J., and Lee, G. S.* (2008) Effect of postural change on nasal airway and autonomic nervous system established by rhinomanometry and heart rate variability analysis. American Journal of Rhinology 22:159-165

77.  Li, J. Y., Kuo, T. B. J., Hsieh, S. S., and Yang, C. C. H.* (2008) Changes in electroencephalogram and heart rate during treadmill exercise in the rat. Neuroscience Letters 434:175-178

78.  Kuo, T. B. J., Shaw, F. Z., Lai, C. J., and Yang, C. C. H.* (2008) Asymmetry in sympathetic and vagal activities during sleep-wake transitions. Sleep 31:311-320

79.  Lai, I. C.*, Yang, C. C. H., Kuo, T. B. J., Wang, Y. C., and Shieh, K. R. (2008) Immediate impact of electroconvulsive therapy on cardiac autonomic function in schizophrenia: A preliminary study. Schizophrenia Research 100:353-355

80.  Harnod, T., Yang, C. C. H., Hsin, Y. L., Shieh, K. R., Wang, P. J., and Kuo, T. B. J.* (2008) Heart rate variability in children with refractory generalized epilepsy. Seizure: European Journal of Epilepsy 17:297-301

81.  Liou, H. L., Chao, Y. F., Kuo, T. B. J., and Chen, H. I.* (2008) Physiological, psychological and autonomic responses to pre-operative instructions for patients undergoing cardiac surgery. Chinese Journal of Physiology 51:317-323

82.  Yi, C. H., Chen, C. L.*, Kuo, T. B. J., and Yang, C. C. H. (2008) The effect of acid suppression on sleep and cardiac autonomic regulation in GERD. Hepatogastroenterology 55:1649-1652

83.  Chen, C. L.*, Yi, C. H., Kuo, T. B. J., and Yang, C. C. H. (2008) Effect of acid suppression on gastric myoelectrical activity in GERD. Hepatogastroenterology 55:1353-1355

84.  Fu, C. H., Yang, C. C. H., Lin, C. L., and Kuo, T. B. J.* (2008) Alteration of cardiovascular autonomic functions by vegetarian diets in postmenopausal women is related to LDL cholesterol levels. Chinese Journal of Physiology 51:100-105

85.  Lee, G. S., Hsiao, T. Y., Yang, C. C. H., and Kuo, T. B. J.* (2007) Effects of speech noise on vocal fundamental frequency using power spectral analysis. Ear and Hearing 28:343-350

86.  Chen, C. L., Yang, C. C. H., and Kuo, T. B. J.* (2007) Transfer function analysis of heart rate variability correlated with gastric myoelectrical activity using a liquid nutritional meal compared to water: are they different? Chinese Journal of Physiology 50:271-276

87.  Chen, K. Y., Chen, C. L.*, Yang, C. C. H., and Kuo, T. B. J. (2006) Cardiac autonomic dysregulation in patients with acute hepatitis. American Journal of the Medical Sciences 332:164-167

88.  Chen, C. L.*, Orr, W. C., Yang, C. C. H., and Kuo, T. B. J. (2006) Cardiac autonomic regulation differentiates reflux disease with and without erosive esophagitis. Scandinavian Journal of Gastroenterology 41:1001-1006

89.  Fu, C. H., Yang, C. C. H., and Kuo, T. B. J.* (2006) Age-related changes in cerebral hemodynamics and their correlations with cardiac autonomic functions. Neurological Research 28:871-876

90.  Lai, C. J., Yang, C. C. H., Hsu, Y. Y., Lin, Y. N., and Kuo, T. B. J.* (2006) Enhanced sympathetic outflow and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats. Journal of Applied Physiology 100:1974-1982

91.  Lee, G. S., Wang, C. P., Yang, C. C. H., and Kuo, T. B. J.* (2006) Voice low tone to high tone ratio: a potential quantitative index for vowel [a:] and its nasalization. IEEE Transactions on Biomedical Engineering 53:1437-1439

92.  Sun, T. B., Yang, C. C. H., and Kuo, T. B. J.* (2006) Effect of hyperbaric oxygen on cardiac neural regulation in diabetic individuals with foot complications. Diabetic Medicine 23:360-366

93.  Sun, T. B., Yang, C. C. H., Lai, C. J., and Kuo, T. B. J.* (2006) Time course of cardiovascular neural regulation during programmed 20-sec apnea in rats. Critical Care Medicine 34:765-770

94.  Fu, C. H., Yang, C. C. H., Lin, C. L., and Kuo, T. B. J.* (2006) Effects of long-term vegetarian diets on cardiovascular autonomic functions in healthy postmenopausal women. American Journal of Cardiology 97:380-383

95.  Tsai, M. W., Chie, W. C., Kuo, T. B. J., Chen, M. F., Liu, J. P., Chen, T. T., and Wu, Y. T.* (2006) Effects of exercise training on heart rate variability after coronary angioplasty. Physical Therapy 86:626-635

96.  Huang, C. J., Kuok, C. H., Kuo, T. B. J., Hsu, Y. W., and Tsai, P. S.* (2006) Pre-operative measurement of heart rate variability predicts hypotension during general anesthesia. Acta Anaesthesiologica Scandinavica 50:542-548

97.  Kuo, T. B. J., Lai, C. J., Huang, Y. T., and Yang, C. C. H.* (2005) Regression analysis between heart rate variability and baroreflex-related vagus nerve activity in rats. Journal of Cardiovascular Electrophysiology 16:864-869

98.  Fu, C. H., Yang, C. C. H., and Kuo, T. B. J.* (2005) Effects of different classes of antihypertensive drugs on cerebral hemodynamics in elderly hypertensive patients. American Journal of Hypertension 18:1621-1625

99.  Lee, G. S., Yang, C. C. H., Wang, C. P., and Kuo, T. B. J.* (2005) Effect of nasal decongestion on voice spectrum of a nasal consonant-vowel. Journal of Voice 19:71-77

100.  Kuo, T. B. J., and Yang, C. C. H.* (2005) Sleep-related changes in cardiovascular neural regulation in spontaneously hypertensive rats. Circulation 112:849-854

101.  Su, C. F., Kuo, T. B. J., Kuo, J. S., Lai, H. Y., and Chen, H. I.* (2005) Sympathetic and parasympathetic activities evaluated by heart-rate variability in head injury of various severities. Clinical Neurophysiology 116:1273-1279

102.  Chen, H. Y., Kuo, T. B. J., Shaw, F. Z., Lai, C. J., and Yang, C. C. H.* (2005) Sleep-related vagotonic effect of zolpidem in rats. Psychopharmacology (Berl) 181:270-279

103.  Kuo, T. B. J., and Yang, C. C. H.* (2004) Scatterplot analysis of EEG slow-wave magnitude and heart rate variability: an integrative exploration of cerebral cortical and autonomic functions. Sleep 27:648-656

104.  Kuo, T. B. J., Shaw, F. Z., Lai, C. J., Lai, C. W., and Yang, C. C. H.* (2004) Changes in sleep patterns in spontaneously hypertensive rats. Sleep 27:406-412

105.  Hsu, H. Y., Chern, C. M., Kuo, J. S., Kuo, T. B. J., Chen, Y. T., and Hu, H. H.* (2004) Correlations among critical closing pressure, pulsatility index and cerebrovascular resistance. Ultrasound in Medicine and Biology 30:1329-1335

106.  Chen, C. L., Lin, H. H., Orr, W. C., Yang, C. C. H., and Kuo, T. B. J.* (2004) Transfer function analysis of heart rate variability in response to water intake: correlation with gastric myoelectrical activity. Journal of Applied Physiology 96:2226-2230

107.  Lai, H. Y., Yang, C. C. H., Cheng, C. F., Huang, F. Y., Lee, Y., Shyr, M. H., and Kuo, T. B. J.* (2004) Effect of esmolol on positive-pressure ventilation-induced variations of arterial pressure in anaesthetized humans. Clinical Science (Lond) 107:303-308

108.  Kuo, T. B. J., Lai, C. J., Shaw, F. Z., Lai, C. W., and Yang, C. C. H.* (2004) Sleep-related sympathovagal imbalance in SHR. American Journal of Physiology-Heart and Circulatory Physiology 286:H1170-H1176

109.  Yang, C. C. H.*, and Kuo, T. B. J. (2003) Dynamic regulation of arterial blood pressure from the brainstem. Tzu Chi Medical Journal 15:1-12

110.  Liu, C. C., Kuo, T. B. J., and Yang, C. C. H.* (2003) Effects of estrogen on gender-related autonomic differences in humans. American Journal of Physiology-Heart and Circulatory Physiology 285:H2188-H2193

111.  Fu, C. H., Yang, C. C. H., and Kuo, T. B. J.* (2003) Effect of angiotensin II receptor antagonism on cerebral vasomotor reserve in humans. Journal of Cardiovascular Pharmacology 42:714-718

112.  Lai, H. Y., Yang, C. C. H., Huang, F. Y., Lee, Y., Kuo, Y. L., and Kuo, T. B. J.* (2003) Respiratory-related arterial pressure variability as an indicator of graded blood loss: involvement of the autonomic nervous system. Clinical Science (Lond) 105:491-497

113.  Lee, G. S., Yang, C. C. H., and Kuo, T. B. J.* (2003) Voice low tone to high tone ratio--a new index for nasal airway assessment. Chinese Journal of Physiology 46:123-127

114.  Kuo, T. B. J., Chern, C. M., Yang, C. C. H., Hsu, H. Y., Wong, W. J., Sheng, W. Y., and Hu, H. H.* (2003) Mechanisms underlying phase lag between systemic arterial blood pressure and cerebral blood flow velocity. Cerebrovascular Diseases 16:402-409

115.  Chao, A. C., Chern, C. M., Kuo, T. B. J., Chou, C. H., Chuang, Y. M., Wong, W. J., and Hu, H. H.* (2003) Noninvasive assessment of spontaneous baroreflex sensitivity and heart rate variability in patients with carotid stenosis. Cerebrovascular Diseases 16:151-157

116.  Yang, C. C. H., Shaw, F. Z., Lai, C. J., Lai, C. W., and Kuo, T. B. J.* (2003) Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in rats. Neuroscience Letters 336:21-24

117.  Chern, C. M., Kuo, T. B. J., Chao, A. C., Sheng, W. Y., and Hu, H. H. (2003) Spectral analysis of cerebrovascular regulation in patients with autonomic dysfunction. Journal of the Chinese Medical Association 66:393-399

118.  Su, C. F., Kuo, T. B. J., Chang, Y. L., and Loh, T. W. (2002) Alternation of systemic blood pressure, intracranial pressure and power spectrum of blood pressure after tracheal suction in patients receiving craniotomy. Taiwan Critical Care Medicine 4:81-88

119.  Wang, J. D., Kuo, T. B. J., and Yang, C. C. H.* (2002) An alternative method to enhance vagal activities and suppress sympathetic activities in humans. Autonomic Neuroscience 100:90-95

120.  Kuo, T. B. J.*, and Yang, C. C. H. (2002) Sexual dimorphism in the complexity of cardiac pacemaker activity. American Journal of Physiology-Heart and Circulatory Physiology 283:H1695-H1702

121.  Yang, C. C. H., Lai, C. W., Lai, H. Y., and Kuo, T. B. J.* (2002) Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in humans. Neuroscience Letters 329:213-216

122.  Yang, T. F.*, Chan, R. C., Kao, C. L., Chiu, J. W., Liu, T. J., Kao, N. T., and Kuo, T. B. J. (2002) Power spectrum analysis of heart rate variability for cerebral palsy patients. American Journal of Physical Medicine & Rehabilitation 81:350-354

123.  Yang, T. F.*, Wong, T. T., Chang, K. P., Kwan, S. Y., Kuo, W. Y., Lee, Y. C., and Kuo, T. B. J. (2001) Power spectrum analysis of heart rate variability in children with epilepsy. Child's Nervous System 17:602-606

124.  Chen, C. C., Chen, S. A., Tai, C. T., Kuo, T. B. J., Chang, M. S., and Prystowsky, E. N.* (2001) Hyperventilation facilitates induction of supraventricular tachycardia: a novel method and the possible mechanism. Journal of Cardiovascular Electrophysiology 12:1242-1246

125.  Su, C. F.*, Kuo, T. B. J., Yang, C. C. H., and Chen, H. I. (2000) Alternation of autonomic nervous functions and cardiovascular hemodynamics in severe head injury. Taiwan Critical Care Medicine 2:129-139

126.  Yang, C. C. H., and Kuo, T. B. J.* (2000) Impact of pulse pressure on the respiratory-related arterial pressure variability and its autonomic control in the rat. European Journal of Physiology 439:772-780

127.  Yang, C. C. H., Chao, T. C., Kuo, T. B. J., Yin, C. S., and Chen, H. I.* (2000) Preeclamptic pregnancy is associated with increased sympathetic and decreased parasympathetic control of HR. American Journal of Physiology-Heart and Circulatory Physiology 278:H1269-H1273

128.  Kuo, T. B. J., and Yang, C. C. H.* (2000) Altered frequency characteristic of central vasomotor control in SHR. American Journal of Physiology-Heart and Circulatory Physiology 278:H201-H207

129.  Kuo, T. B. J.*, Lin, T., Yang, C. C. H., Li, C. L., Chen, C. F., and Chou, P. (1999) Effect of aging on gender differences in neural control of heart rate. American Journal of Physiology-Heart and Circulatory Physiology 277:H2233-H2239

130.  Chern, C. M., Kuo, T. B. J., Sheng, W. Y., Wong, W. J., Luk, Y. O., Hsu, L. C., and Hu, H. H.* (1999) Spectral analysis of arterial blood pressure and cerebral blood flow velocity during supine rest and orthostasis. Journal of Cerebral Blood Flow  and Metabolism 19:1136-1141

131.  Hu, H. H.*, Kuo, T. B. J., Wong, W. J., Luk, Y. O., Chern, C. M., Hsu, L. C., and Sheng, W. Y. (1999) Transfer function analysis of cerebral hemodynamics in patients with carotid stenosis. Journal of Cerebral Blood Flow  and Metabolism 19:460-465

132.  Yang, C. C. H., and Kuo, T. B. J.* (1999) Assessment of cardiac sympathetic regulation by respiratory-related arterial pressure variability in the rat. Journal of Physiology 515:887-896

133.  Chou, C. L., Kao, N. T., Kuo, T. B. J., Liu, T. J., and Chan, R. C.* (1998) Heart rate variability as an assessment of acute rejection after heart transplantation. Zhonghua Yi Xue Za Zhi (Taipei) 61:561-567

134.  Yang, M. W., Kuo, T. B. J., Lin, S. M., and Chan, S. H. (1998) Power spectral analysis of arterial blood pressure after spinal anesthesia. Acta Anaesthesiologica Sinica 36:3-10

135.  Kuo, T. B. J., Chern, C. M., Sheng, W. Y., Wong, W. J., and Hu, H. H.* (1998) Frequency domain analysis of cerebral blood flow velocity and its correlation with arterial blood pressure. Journal of Cerebral Blood Flow  and Metabolism 18:311-318

136.  Kuo, T. B. J., Yien, H. W., Hseu, S. S., Yang, C. C. H., Lin, Y. Y., Lee, L. C., and Chan, S. H. H.* (1997) Diminished vasomotor component of systemic arterial pressure signals and baroreflex in brain death. American Journal of Physiology-Heart and Circulatory Physiology 273:H1291-H1298

137.  Yang, C. C. H., Kuo, T. B. J., and Chan, S. H. H.* (1997) Functional characterization of caudal hypoglossal neurons by spectral patterns of neuronal discharges in the rat. Neuroscience 77:813-827

138.  Yien, H. W., Hseu, S. S., Lee, L. C., Kuo, T. B. J., Lee, T. Y., and Chan, S. H. H.* (1997) Spectral analysis of systemic arterial pressure and heart rate signals as a prognostic tool for the prediction of patient outcome in the intensive care unit. Critical Care Medicne 25:258-266

139.  Kuo, T. B. J., Yang, C. C. H., and Chan, S. H. H.* (1997) Selective activation of vasomotor component of SAP spectrum by nucleus reticularis ventrolateralis in rats. American Journal of Physiology-Heart and Circulatory Physiology 272:H485-H492

140.  Chang, A. Y. W., Kuo, T. B. J., Chan, J. Y. H., and Chan, S. H. H.* (1996) Concurrent elicitation of electroencephalographic desynchronization and penile erection by cocaine in the rat. Synapse 24:233-239

141.  Kuo, T. B. J., Yang, C. C. H., and Chan, S. H. H.* (1996) Transfer function analysis of ventilatory influence on systemic arterial pressure in the rat. American Journal of Physiology-Heart and Circulatory Physiology 271:H2108-H2115

142.  Kuo, T. B. J., Yang, C. C. H., Chan, J. Y. H., Tsai, H. F., and Chan, S. H. H.* (1996) Further Characterization of Nociception-Related and Arterial Pressure-Related Neuronal Responses in the Nucleus Reticularis Gigantocellularis of the Rat. Journal of Biomedical Science 3:338-347

143.  Wang, H., Kuo, T. B. J., Chan, S. H. H., Tsai, T. H., Lee, T. Y., and Lui, P. W.* (1996) Spectral analysis of arterial pressure variability during induction of propofol anesthesia. Anesthesia and Analgesia 82:914-919

144.  Yang, C. C. H., Kuo, T. B. J., and Chan, S. H. H.* (1996) Auto- and cross-spectral analysis of cardiovascular fluctuations during pentobarbital anesthesia in the rat. American Journal of Physiology-Heart and Circulatory Physiology 270:H575-H582

145.  Yang, C. H., Shyr, M. H., Kuo, T. B. J., Tan, P. P. C., and Chan, S. H. H.* (1995) Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat: correlation with plasma concentration. Journal of Pharmacology and Experimental Therapeutics 275:1568-1574

146.  Chang, A. Y. W., Kuo, T. B. J., Tsai, T. H., Chen, C. F., and Chan, S. H. H.* (1995) Power spectral analysis of electroencephalographic desynchronization induced by cocaine in rats: correlation with evaluation of noradrenergic neurotransmission at the medial prefrontal cortex. Synapse 21:149-157

147.  Yang, M. W., Kuo, T. B. J., Lin, S. M., Chan, K. H., and Chan, S. H. H.* (1995) Continuous, on-line, real-time spectral analysis of SAP signals during cardiopulmonary bypass. American Journal of Physiology-Heart and Circulatory Physiology 268:H2329-H2335

148.  Chang, C. C., Yang, M. W.*, Lin, S. M., Kuo, T. B. J., Chan, K. H., and Lin, C. Y. (1995) Power spectral analysis of systemic arterial pressure signals during open heart surgery. Zhonghua Yi Xue Za Zhi (Taipei) 55:421-426

149.  Yang, C. C. H., Kuo, T. B. J., Chan, S. H. H., and Chan, J. Y. H.* (1995) Neurobiology of central angiotensin III and dipsogenesis. Biological Signals 4:59-71

150.  Chang, A. Y. W., Kuo, T. B. J., and Chan, S. H. H.* (1994) Power spectral analysis of electroencephalographic desynchronization induced by cocaine in the rat. Neuroscience Letters 170:175-178

151.  Lee, T. Y., Fu, M. J., Kuo, T. B. J., Lui, P. W., and Chan, S. H. H.* (1994) Power spectral analysis of electromyographic and systemic arterial pressure signals during fentanyl-induced muscular rigidity in the rat. British Journal of Anaesthesia 72:328-334

152.  Chan, J. Y. H., Tsai, H. F., Kuo, T. B. J., and Chan, S. H. H.* (1994) Modulation by angiotensin III of nociception-related and arterial pressure-related neuronal responsiveness in the nucleus reticularis gigantocellularis of the rat. Regulatory Peptides 50:247-257

153.  Luoh, H. F., Kuo, T. B. J., Chan, S. H. H., and Pan, W. H. T.* (1994) Power spectral analysis of electroencephalographic desynchronization induced by cocaine in rats: correlation with microdialysis evaluation of dopaminergic neurotransmission at the medial prefrontal cortex. Synapse 16:29-35

154.  Lee, B. P.*, Chen, H. F., Hsu, F. C., Kuo, T. B. J., and Yang, M. H. (1994) Effects of pulmonary air embolism on discharge of slowly adapting pulmonary stretch receptors. Journal of Applied Physiology 76:97-103

155.  Tsai, H. F., Kuo, T. B. J., Chan, J. Y. H., and Chan, S. H. H.* (1994) Interaction between neuronal responses to nociception and hypertension in the nucleus reticularis gigantocellularis of the rat. Neuroscience Letters 165:137-140

156.  Tan, P. P. C., Shyr, M. H., Yang, C. H., Kuo, T. B. J., Pan, W. H. T., and Chan, S. H. H.* (1993) Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: intravenous infusion. Neuroscience Letters 160:205-208

157.  Shyr, M. H., Yang, C. H., Kuo, T. B. J., Pan, W. H. T., Tan, P. P. C., and Chan, S. H. H.* (1993) Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: intravenous bolus administration. Neuroscience Letters 153:161-164

158.  Kuo, T. B. J., Shyr, M. H., and Chan, S. H. H.* (1993) Simultaneous, continuous, on-line and real-time spectral analysis of multiple physiologic signals by a personal-computer-based algorithm. Biological Signals 2:45-56

159.  Kuo, T. B. J., and Chan, S. H. H.* (1993) Continuous, on-line, real-time spectral analysis of systemic arterial pressure signals. American Journal of Physiology-Heart and Circulatory Physiology 264:H2208-H2213

160.  Kuo, T. B. J., and Chan, S. H. H.* (1992) Extraction, discrimination and analysis of single-neuron signals by a personal-computer-based algorithm. Biological Signals 1:282-292

161.  Kuo, T. B. J.*, and Chan, S. H. H. (1991) Power spectral analysis of systemic arterial pressure in the rat: correlation with pentobarbital anesthesia. Chinese Journal of Biomedical Engineering 11:54-58


 



已通過及申請中專利案件

過去已通過專利案件 (台灣)

類別 專利名稱 國別 專利號碼 發明人 專利權人 專利核准日 期
B 評估自主神經系統功能之自動遠端控制方法及系統 中華民國 168747 郭博昭 郭博昭
麗臺
2002/12/11-2021/12/06
B 能由頸部同時測量心電、脈搏和聲波訊號之感測器 中華民國 169688 郭博昭 郭博昭
麗臺
2003/01/01
-2021/11/20
B 非侵入性自律神經系統監測儀器系統及其用途 中華民國 176323 郭博昭孫德銓 郭博昭工研院 2003/03/21-2022/03/31
B 以聲音低高頻比作為鼻腔及鼻音監測的方法 中華民國 195701

郭博昭 李國熙

郭博昭 李國熙 2004/01/11-2022/07/01
B 陰陽虛實之偵測方法及其裝置 中華民國 198840 郭博昭

郭博昭 楊靜修麗台

 

2004/04/01-2023/03/10
B 聚合脢連鎖反應儀結構改良 中華民國 224760

鄧俊男

郭博昭

郭博昭 2004/01/11 - 2022/07/01
B 心電訊號轉換器及其類比-數位轉換單元 中華民國 222861 郭博昭 郭博昭 2004/11/01 - 2023/06/24
B 鼻音偵測方法及其裝置 中華民國 226600

李國熙

郭博昭

郭博昭 李國熙

2004/09/09
B 心率變異性分析方法及裝置。 中華民國 225394 郭博昭楊靜修 郭博昭楊靜修 2004/12/31-2023/05/13
B 心電訊號轉換器及其類比-數位轉換單元 中華民國 222861 郭博昭 郭博昭楊靜修 2004/11/01-2023/06/24
B 聽力與發聲腦幹之檢測方法及其裝置 中華民國 200616866

李國熙

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李國熙

郭博昭

2006/09-2024/01
B 脈衝間距至電壓轉換器及其轉換方法 中華民國 261415 郭博昭 楊靜修 郭博昭 楊靜修麗台 2006/09/01-2023/05/20
B 多頻道之脈衝間距至電壓轉換器及轉換方法 中華民國 I254504 郭博昭 楊靜修 郭博昭楊靜修麗台 2006/05/01-2024/04/06
B 貼片式無線微生理訊號收集裝置 中華民國 I31190 郭博昭楊靜修 郭博昭楊靜修享翔顧問有限公司 2009/07/11-2026/01/12
B 微型無線心電訊號收集裝置. 中華民國 I313593 郭博昭楊靜修 郭博昭楊靜修 2009/08/21-2025/11/27
B 耳機感測式心電訊號量測系統 中華民國 I316401 郭博昭 楊靜修 郭博昭楊靜修 享翔顧問有限公司 2009/11/01-2026/06/20
B 太陽眼鏡型瞌睡防止器 中華民國 I321227 郭博昭楊靜修 國立陽明大學 2010/03/01-2027/04/17
B 項鍊型心電及體溫訊號偵測器 中華民國 I337536 郭博昭 楊靜修 國立陽明大學 2011/02/21-2027/05/14
B 觸控式電子裝置使用狀態監控系統 中華民國 M455306

林煜軒
郭博昭
李揚漢
錢威
曾憲威

林煜軒
郭博昭
李揚漢
錢威
曾憲威

2013/6/11-
2023/1/2

B

行為模式分析方法

中華民國 I437458 郭博昭
楊靜修
國立陽明大學 2014/5/11-
2030/7/26
B 具無線傳輸之資料緩衝裝置 中華民國 I432070 郭博昭
楊靜修
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2030/10/5

過去已通過專利案件 (美國)

專利名稱 國別 專利號碼 發明人 專利權人 專利核准日 期
B Electrocardiogram
signal collecting apparatus
美國 6360117 郭博昭 郭博昭 2002/03-
2019/05
B Non-invasive apparatus system for monitoring autonomic nervous system and uses thereof. US Patent 美國 6,811,536 B2 郭博昭
孫德銓

郭博昭
工研院

2004/01-
2022/07
B Pulse interval to voltage converter and conversion method thereof 美國 6,989,693 郭博昭
楊靜修
郭博昭
楊靜修
麗臺
2006/01/24-2024/03/17
B Methods and Apparatus for Analyzing Heart Rate Variability 美國 7,277,746 郭博昭
楊靜修
郭博昭
楊靜修

2007/10/02-2026/04
B Miniature wireless apparatus for collecting physiological signals 美國 7,672,714 B2 郭博昭
楊靜修
郭博昭
楊靜修
享翔顧問有限公司
2010/03-
2027/04
B Earphone sensor system for measuring electrocardiogram signals 美國 7,769,435 B2 郭博昭
楊靜修
郭博昭
楊靜修
享翔顧問有限公司
2010/08-
2027/09
B Sleep analysis system and method for analyzing sleep thereof. US Patent
美國 8,292,819 B2
郭博昭
楊靜修
國立陽明大學
2012/12-

2030/01

A Analysis module, cloud analysis system and method thereof. 美國

0067838 A1

黃锷
羅孟宗
郭博昭
林佑正
國立中央大學 2014/3/6-2034/3/7


過去已通過專利案件 (大陸)

專利名稱 國別 專利號碼 發明人 專利權人 專利核准日 期
B 陰陽虛實之偵測方法及其裝置 大陸 ZL03109155.5 郭博昭
楊靜修
郭博昭
楊靜修
麗臺
2006/07/12-2023/04/02
B 脈衝間距至電壓轉換器及其轉換方法 大陸 ZL03143197.6 郭博昭
楊靜修
郭博昭
楊靜修
麗臺
2006/08/30-2023/06/05




國內外技術轉移或產學合作

技術名稱 專利名稱 授權單位
微型心電發報器 貼片式無線微生理訊號收集裝置
微型無線心電訊號收集裝置
麗台公司
心率變異分析儀 心率變異分析心電轉換器 威今公司
名片型心電圖/肌電圖分析儀 名片型心電圖/肌電圖分析儀 陽明大學
無線傳輸模組技術 超低功率無線傳輸模組技術授權契約 大同生科股份有限公司
藍芽與神農及HRV無線傳輸晶片 藍芽與神農及HRV無線傳輸晶片模組 大同生科股份有限公司
Xenon IID模組技術 Xenon IID模組技術授權契約 少華股份有限公司
神農無線傳輸模組及路由器 神農無線傳輸模組及路由器與無線射頻外接盒 麗臺科技股份有限公司
標準型腦波儀 太陽眼鏡型瞌睡防止器 聯合利得國際投資有限公司

 

 

研究成果說明

近五年主要研究成果說明

從事研究或創作過程

吾人自高一 (1983年) 起自修程式設計,以組合語言計算圓周率至一萬位。榮獲高雄中學程式設計比賽分組冠軍。自製程式分析生物實驗數據,獲全國科展第三名。1986年起自修數位與類比電路設計,自組6502微電腦系統,進行計時、類比-數位轉換等功能。

1986年進入陽明大學醫學系,大三進入呼吸生理實驗室,將電腦技能發揮到生物醫學研究上,自修數位訊號處理,完成呼吸生理分析程式。隔年完成神經訊號分析程式。大四轉到神經藥理實驗室進行循環律動研究。隔年完成個人電腦用類比數位轉換器及連續、即時、線上的血壓頻譜分析程式。1993年大學畢業時已發表6篇論文。

1993年攻讀碩博士,以血壓的動態調控為研究主題,設計一系列的電路與程式,包括可程式電刺激器、可程式呼吸器與轉換函數分析程式等。同時也利用這些工具進行人體與動物實驗,發現血壓頻譜可以預測病人生死。開發第一代生理律動分析系統,又稱為「算命機」。1996年博士畢業時已發表22篇論文。

1996年任職陽明大學醫學系副教授,設計程式與電路進行腦血流與心跳律動的研究期間設計心電收集器獲得台、美專利。完成第二代生理律動分析系統,分別榮獲基礎神經科學會與資訊學會之「青年研究獎」。

2000年後任職慈濟大學神經科學研究所教授,成立自律神經研究團隊,經營「東台灣睡眠研究中心」,使用自己開發之儀器及程式進行醫工、基礎與臨床醫學整合。持續新一代生理律動分析系統的開發,並將實驗儀器產品化。2002年榮獲「國家生技品質獎」。2004年獲選為「十大傑出青年」。

2006年回陽明大學任教。曾擔任腦科學研究所所長、研發長,將先前累積的知識與經驗,協助母校在腦科學研究與產業合作的發展。並與中央大學黃鍔院士合作,將其發明的分析技術 (HHT),引入生醫研究。與交通大學林進燈教授合作,將生醫科技轉至資訊產業。就近與多家北部的公司開發新ㄧ代小型無線醫療保健用品。

六個研究方向:

一、醫學工程研究

  從1988年開始實驗用電腦程式的創作,首先獲得陽明大學生理學研究所的採用 (Lee et al., 1994)。之後進一步從事儀器電路的設計。譬如1996年設計的心電訊號擷取器,獲得台灣 (Kuo, 1999) 與美國專利 (Kuo, 2002),衍生數篇研究論文 (Kuo et al., 1999; Yang et al., 2000; Kuo and Yang, 2002; Wang et al., 2002; Yang et al., 2002; Liu et al., 2003; Chen et al., 2001; Yang et al., 2001; Fu et al., 2003; Chen et al., 2004 ),並與一家生技公司開發商用機型 (www.wegene.com.tw),獲得經濟部之國家生技品質獎,之後通過衛生署之醫療儀器認証。其它已公開 (Lee et al., 2003) 與未公開的專利與技術則不再贅述。這方面的發展除了支援本團隊實驗室的生物醫學研究外,也提供給不少同好使用。近期更集合過去所有軟、硬體醫學工程研究之大成,開發世界上最小、最省電且多功能無線生理感測系統及其各式應用,近年的計畫乃採用此設計進行後續各式產學開發、臨床及基礎研究。

二、血壓變異性 (BPV) 研究

  從1991年持續開發至今未曾間斷 (Kuo and Chan, 1991),比較特殊的例子包括「算命機」等 (Kuo et al., 1997a; Yien et al., 1997)。1998年後持續新題材的研發,譬如首創BPV中的呼吸成份能代表心臟交感神經活性 (Yang and Kuo, 1999),並進而提出其作用機轉 (Yang and Kuo, 2000;Yang et al., 2008)。首先發現高血壓鼠延腦調控血壓的能力數倍於正常血壓鼠 (Kuo and Yang, 2000)。解釋BPV呼吸成份為何能反應體液多寡的生理機轉 (Lai et al., 2003)。以中文寫一篇論文交待這方面的研究 (Yang and Kuo, 2003)。2005年接受國立中國醫藥研究所的委託,進行脈診儀之改良工作,希望將中醫與西醫的技術整合與推廣,其成果已寫成專利,並有研究成果(Kung et al., 2011)。

三、心率變異性 (HRV) 研究

從1996年後採用歐美公認的方法進行分析工具的建立,並進行人體與動物研究。1997年後持續新題材的開發,與陽明大學公衛所合作,建立全球先驅的正常人資料庫,清楚呈現年齡與性別的影響 (Kuo et al., 1999),這篇論文後來受到廣泛的引用,並被歐洲學者視為重要的發現。之後對心跳動態性別差異的現象深入研究 (Kuo and Yang, 2002),這方面的成果受到美國生理學會的重視並發送新聞稿給國際媒體 (http://www.the-aps.org/press/journal/release11-5-02-3.htm),而本團隊又進一步證實此性別差異的決定因素是女性荷爾蒙 (Liu et al., 2003)。提出子癲前症伴隨著心臟自律神經異常 (Yang et al., 2002) 並與神經外科合作確認HRV能反應頭部外傷的嚴重性 (Su et al., 2000);與心臟內科合作探討心律不整的機轉 (Chen et al., 2001);與復健科共同研究癲癇與腦性痲痺的病理 (Yang et al., 2002; Yang et al., 2001);與中醫科合作探討針灸的機轉 (Wang et al., 2002);

與腸胃科合作開發評估胃自律神經功能的新方法 (Chen et al., 2004);與神經內科確認頸動脈手術對感壓反射的影響 (Chao et al., 2003) 與神經外科探索癲癇病人的自主神經功能變化 (Harnod et al., 2009; Harnod et al., 2008Hsin et al., 2010);與泌尿科探索男性功能障礙中心臟自主神經之角色 (Chen et al., 2008);與精神科探索精神用藥或治療對心臟自律神經功能的影響 (Chen et al., 2005; Lai et al., 2008; Wang et al., 2008; Lai et al., 2010; Chang et al., 2011; Huang et al., 2012a; Wang et al., 2012a; Wang et al., 2012b);與精神科探索實習醫師的壓力問題 (Lin et al., 2012)。另也瞭解美沙冬對毒物成癮的替代療法對心臟自律神經功能的影響 (Chang et al., 2012; Huang et al., 2012b)。

四、腦血流變異性研究

  從1998年開始相關論文的發表,與台北榮總腦血管病科合作,首創腦血管功能的非侵體分析方法 (Kuo et al., 1998),並進而證實其臨床重要性 (Chern et al., 1999; Hu et al., 1999)。後來這些論文受到廣泛的引用,成為此方研究的先驅。本團隊更進一步提出腦血流與血壓互動的機轉 (Kuo et al., 2003),並首度提出angiotensin Ⅱ擷抗劑能改善人體腦血管的功能 (Fu et al., 2003)。

五、睡眠研究

由於睡眠研究必須整合工程、生理、心理與行為科學,被視為難度較高的研究。經由神經內科、生理學科及神經科學研究所共同合作,本團隊於2002年首度發表睡眠相關的論文,以自創的方法提出人體睡眠深度與自主神經功能的相關 (Yang et al., 2002),之後在大鼠重現類似的結果 (Yang et al., 2003)。以此為基礎,進一步發現高血壓大鼠雖然於清醒時和正常鼠有類同的自主神經活性,在睡眠時即呈現較強的交感神經活性 (Kuo et al., 2004a)。開發新的睡眠定量分析法,發現高血壓鼠的睡眠品質遜於正常鼠 (Kuo et al., 2004b)。也找出高血壓鼠之睡眠異常問題可能是交感1-adrenergic system過度興奮有關 (Kuo et al., 2012b)。為了將複雜的睡眠資料以更簡單的方式呈現,持續改良先前的方法,進一步提出一種有效研究腦波與自主神經互動的新方法 (Kuo and Yang, 2004)。2005年我們在睡眠、自主神經與高血壓互動的研究成果獲得循環學權威期刊 Circulation的青睞,並得到編審委員的專文介紹 (http://circ.ahajournals.org/cgi/content/full/112/6/786)。我們也將自主神經功能與睡醒變化的可能因果關連作一探討,了解自主神經功能變化可能是切換睡醒的重要原因之一,也提出了可能假說 (Kuo et al., 2008)。近年我們更建立完全的無線大鼠模式,除了在測量上動物能更自由,更無壓力外,也使記錄時間可以延長,使有機會了解超過24小時之正常生理律動 (Hsieh et al., 2012);已知睡眠後期好發心循環疾病,我們也確立了大鼠的類似模式,了解期間可能與睡眠後期睡眠結構的不穩定與自律神經偏向交感端有關 (Kuo et al., 2012c);小鼠類似的研究模式在技術上更難,技術上我們也已建立完成,目前論文正投稿中。此部分研究也由於完全無線技術且無時限技術開發而達更完美階段,發現及論文陸續撰寫中。

六、雜項研究

  自1997年起擔任博士生的指導教授,開始往作育英才的方向努力。由於不少進修者是在職的醫師,如何讓他們同時兼顧職業與學業,並導引至 Translational Research,成為一個新的挑戰。為了發揮每位進修者的特色,我們開發了不少新的研究領域,包括嗓音分析 (Lee et al., 2005; Lee et al., 2006)、高壓氧與缺氧研究
(Sun et al., 2006b; Sun et al., 2006a) 、素食研究 (Fu et al., 2006)與運動及行為等相關研究 (Li et al., 2008; 2012; Kuo et al., 2010; 2011; Chen et al., 2011) 等,已建立初步的基礎。

 

六個研究特色:

一、原創
本人所有知識與技能都是在台灣學習,有關電子、電腦方面的技能都是靠不斷的自修而精進。雖然過程緩慢,但有助於達成高度的原創性,進而建立團隊在國際舞臺的特色,增加國際競爭力。

二、自製電子線路
本人實驗室大部份的儀器是自製的,包括心電儀、腦波儀、體溫計等。除了能節省開支外,更重要的是有能力製作多樣的儀器平臺進行各類的實驗,滿足日漸繁忙的研究工作。也可以提供大量的硬體設備給國內外同好,支援整合型研究的硬體需求。

三、自製電腦程式
本人實驗室所用的核心分析程式都是自製的,包括資料擷取、定量、頻譜分析、睡眠分期等。除了節省開支外,更重要的是能主導研究方向,免除受限於外人之苦。也能隨時修正與新增程式,以最快的速度將抽象的理論概念轉變成實驗室的分析工具,進行生物醫學應用。這方面的成果榮獲2000年中華民國資訊學會之「李國鼎」青年研究獎。

四、自創理論與制定規格
在硬體與軟體上的自主性,我們得以設計並嘗試一些前所未有的分析理論,從1993年發表在美國生理學期刊“Special Communication” (是一個發表新方法的專欄)起,在本人主導的研究論文中即經常嘗試新的研究方法。反之,同樣的方法很少連續發表超過兩篇的論文,如此做法當然不利於論文的“量產”,但求落實一個創新突破的精神。

五、基礎與臨床整合
醫學研究不僅是純理論的研究,必須實際上能在日常生活應用,能為病患“拔苦與樂”才能突顯其價值,所以從實驗室走向醫院是必然的過程,但這個過程通常是緩慢而艱難的。為了加快腳步,我們積極與臨床環境接觸。譬如本人曾在醫院接受住院醫師的訓練,回到教學單位後,對於前來進修的醫師皆抱以積極歡迎的態度,為每位合作的醫師訂製分析工具以利其收集病患的資料。在種種努力下,得以達到一些臨床應用的成果,而這些寶貴的經驗又有助於未來研究方向的擬定。這方面的努力曾榮獲1999年中華民國基礎神經學會之「王世濬」青年研究獎, 2004並獲選為「中華民國十大傑出青年」。

六、產學合作
當一個研究成果通過了基礎醫學與臨床醫學的驗證後,就應進行國內與國際上的推廣,才能幫助更多的人並發揮實際上的影響力 (impact)。為了達到此目的,商品化是最有效率而且能持久的方法。我們這方面也努力吸收了一些經驗,目前與生
技公司合作開發新型的醫療儀器,並成功通過衛生署醫療儀器的認証,正式在市面上流通,也獲得經濟部「國家生技品質獎」、「2006日本設計獎」及「國家生技醫療品質獎」的肯定。去年更完成一項產學合作,推出完全自創微型無線多功能生理記錄儀,並已獲美國FDA認證,其各式應用正式開始。

 

 

 

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