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師資 faculty

神經資訊造影暨工程組

 

陳麗芬 教 授
Ph.D.

陽明大學 腦科學研究所 專任教授/副所長
陽明大學 生物資訊研究所 合聘教授
臺北榮總 醫研部 特約研究員

Tel: (02) 2826-7384
Fax: (02) 2827-3123

E-mail : lfchen@ym.edu.tw

研究室網頁

 

 

研究專長

生醫工程、腦造影、資訊科學


研究概況

陳麗芬老師目前是腦科學研究所教授兼副所長,其所主持的腦造影實驗室(Brain Mapping Labratory, BML)著重於開發創新腦訊號與影像處理技術,利用腦電磁波訊號(EEG, MEG)與磁振造影影像(MRI),結合機器學習技術,研究人腦感知歷程、認知功能、情緒處理、與疼痛迴路等等, 建構神經網路與資訊傳遞模型,藉以進一步瞭解人腦運作思考模式,以及探討臨床疾病之神經病理機轉(如憂鬱症、躁鬱症、思覺失調症、原發性經痛等)與經由長期學習所建構之神經可塑性。同時我們亦開發人工智慧技術,發展以腦波與腦影像為基礎之電腦輔助診斷、評估治療、與預測之系統平台。 目前正在進行之研究方向如下:
1. 利用腦磁圖與磁振造影探索打擊樂音樂家之大腦
2. 運用深度學習技術解析聆聽音樂誘導腦波之神經表徵
3. 利用腦磁圖與磁振造影探討原發性痛經腦部網路交互作用與基因多型性之關聯
4. 經顱直流電刺激於嚴重難治型原發性痛經之神經調節效益
5. 以音樂與聽覺神經振盪同步化緩解疼痛與焦慮之神經調控技術開發
6 腦電磁圖神經網路有效性連結分析技術開發
7. 以人工智慧評估脈絡膜視網膜病變
8. 阿茲海默症人工智慧評估與診斷系



研究

實驗室: 腦造影實驗室 整合性腦功能研究小組


研究興趣


The Brain Mapping Laboratory aims at the development of pioneer approaches for extracting significant information from brain signals to understand the function and structure of the human brain. Our major goals include:
  • Developing medical image processing techniques for manipulating, morphologically measuring, statistically inferring,and visualizing brain structures of normal subjects and patients.
  • Developing signal processing and electromagnetic mapping technologies for functional imaging of human brains.
  • Imaging cognitive/emotional information processing and constructing the model of emotion regulation in healthy and diseased brains
  • Developing brain informatics and data mining techniques for exploring structure-function association in brain image-signal database

學術獎項

2016 Outstanding Award, 2016 Annual Thesis Competition, 國立陽明大學105學年度學術論文研討會醫學技術及工程組博士班優等獎

2015 台灣生物精神醫學會年會壁報獎 (共兩篇獲獎)

2015 Oral presentation and Contributed paper, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS)

2014 Best Paper, Student Paper Oral Competition, 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering 2014

2014 台灣生物精神醫學會年會壁報獎

2013 生物醫學工程科技研討會壁報展示優等獎

2009 Engineering Paper Award, Chinese Institute of Engineers, 中國工程師學會 工程論文獎

2009 Best Poster Award, 臺灣職能治療學會第28次學術研討會, 特優海報論文獎

2008 Best Annual Paper Award, Journal of Medical and Biological Engineering,

2008 Best Paper Award, 臺灣職能治療學會第27次學術研討會暨第一屆職能科學論壇, (特優口頭發表論文獎)

2004 電腦視覺、圖形暨影像處理會議 佳作論文獎

2004 醫工年會 國科會計畫論文壁報發表第三名

2003 Journal of Imaging Science and Technology, 最佳論文獎

2000 電腦視覺、圖形暨影像處理會議 佳作論文獎

2000 中華民國資訊學會 最佳碩博士論文獎 佳作獎



論文著作 (2000 - 2018) (2015 Impact Factor)

[Journal Papers] (*: corresponding author)

  1. Po-Chih Kuo, Yong-Sheng Chen, Li-Fen Chen* (2018). Manifold decoding for neural representations of face viewpoint and gaze direction using magnetoencephalographic data. Human Brain Mapping, in press. [SCI]

  2. Intan Low, Po-Chih Kuo, Yu-Hsiang Liu, Cheng-Lin Tsai, Hsiang-Tai Chao, Jen-Chuen Hsieh, Li-Fen Chen*, Yong-Sheng Chen* (2017). Altered brain complexity in women with primary dysmenorrhea: a resting-state MEG study using multiscale entropy analysis. Entropy, 19(12):680. [SCI, IF=1.821, RF=0.33 (26/79), PHYSICS, MULTIDISCIPLINARY]

  3. Pin-Shiuan Lee, Intan Low, Yong-Sheng Chen, Cheng-Hao Tu, Hsiang-Tai Chao, Jen-Chuen Hsieh, Li-Fen Chen* (2017). Encoding of menstrual pain experience with theta oscillations in women with primary dysmenorrhea. Scientific Reports 7:15977. [SCI, IF=5.228, RF=0.111 (7/63), MULTIDISCIPLINARY SCIENCES]

  4. Shyh-Yuh Wei, Li-Fen Chen, Ming-Wei Lin, Wei-Chi Li, Intan Low, Ching-Ju Yang, Hsiang-Tai Chao, Jen-Chuen Hsieh (2017). The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea. Scientific Reports, 7:39906. [SCI, IF=5.228, RF=0.111 (7/63), MULTIDISCIPLINARY SCIENCES]

  5. Po-Chih Kuo, Yi-Ti Chen, Yong-Sheng Chen*, Li-Fen Chen (2017). Decoding the perception of endogenous pain from resting-state MEG. NeuroImage, 144:1–11. [SCI, IF=5.463, RF=0.057 (7/124), RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING]

  6. Wei-Chung Mao, Li-Fen Chen*, Chia-Hsing Chi, Ching-Hung Lin, Yu-Chen Kao, Wen-Yau Hsu, Hsien-Yuan Lan, Jen-Chuen Hsieh* (2016). Traditional Chinese version of the Mayer Salovey Caruso Emotional Intelligence Test (MSCEIT-TC): Its validation and application to schizophrenic individuals. Psychiatry Research, 243:61-70. [SCI, IF=2.466, RF=0.443 (62/140), PSYCHIATRY]

  7. Ting-Hsuan Wu, Cheng-Hao Tu, Hsiang-Tai Chao, Wei-Chi Li, Intan Low, Chih-Ying Chuang, Tzu-Chen Yeh, Chou-Ming Cheng, Chih-Che Chou, Li-Fen Chen*, Jen-Chuen Hsieh* (2016). Dynamic changes of functional pain connectome in women with primary dysmenorrhea. Scientific Reports, 24(6): 24543. [SCI, IF=5.228, RF=0.111 (7/63), MULTIDISCIPLINARY SCIENCES]

  8. Shyh-Yuh Wei, Hsiang-Tai Chao, Cheng-Hao Tu, Ming-Wei Lin, Wei-Chi Li, Intan Low, Horng-Der Shen, Li-Fen Chen*, Jen-Chuen Hsieh* (2016). BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea. Scientific Reports, 24(6): 23639. [SCI, IF=5.228, RF=0.111 (7/63), MULTIDISCIPLINARY SCIENCES]

  9. Po-Chih Kuo, Yong-Sheng Chen*, Li-Fen Chen (2015). Supervised learning for neural manifold using spatiotemporal brain activity. Journal of Neural Engineering, 12(6):066025 (12pp). [SCI, IF=3.493, RF=0.132 (10/76), BIOMEDICAL ENGINEERING]

  10. Shyh-Yuh Wei, Hsiang-Tai Chao, Cheng-Hao Tu, Wei-Chi Li, Intan Low, Chih-Ying Chuang, Li-Fen Chen, Jen-Chuen Hsieh* (2016). Changes in functional connectivity of pain modulatory systems in women with primary dysmenorrhea. Pain, 157:92–102. [SCI, IF=5.557, RF=0.065 (2/31), ANESTHESIOLOGY]

  11. Hui-Ling Chan, Li-Fen Chen, I-Tzu Chen, Yong-Sheng Chen* (2015). Beamformer-based spatiotemporal imaging of linearly-related source components using electromagnetic neural signals. NeuroImage, 114:1-17. [SCI, IF=5.463, RF=0.057 (7/124), RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING]

  12. Tai-Ying Liu, Yong-Sheng Chen, Jen-Chuen Hsieh, Li-Fen Chen* (2015). Asymmetric engagement of amygdala and its gamma connectivity in early emotional face processing. PLoS ONE 10(1):e0115677. [SCI, IF=3.057, RF=0.175 (11/63), MULTIDISCIPLINARY SCIENCES]

  13. Wei-Chi Li, Cheng-Hao Tu, Hsiang-Tai Chao, Tzu-Chen Yeh, Li-Fen Chen, Jen-Chuen Hsieh* (2015). High prevalence of incidental brain findings in primary dysmenorrhea. European Journal of Pain 19(8):1071-4. [SCI, IF=2.900, RF=0.290 (9/31), ANESTHESIOLOGY]

  14. Lin-Chien Lee, Cheng-Hao Tu, Li-Fen Chen, Horng-Der Shen, Hsiang-Tai Chao, Ming-Wei Lin, Jen-Chuen Hsieh* (2014). Association of brain-derived neurotrophic factor gene Val66Met polymorphism with primary dysmenorrhea. PLoS ONE 9(11): e112766. doi:10.1371/journal.pone.0112766. [SCI, IF=3.057, RF=0.175 (11/63), MULTIDISCIPLINARY SCIENCES]

  15. Po-Chih Kuo, Yong-Sheng Chen*, Li-Fen Chen*, Jen-Chuen Hsieh (2014). Decoding and encoding of visual patterns using magnetoencephalographic data represented in manifolds. Neuroimage 102:435-450. [SCI, IF=5.463, RF=0.057 (7/124), RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING]

  16. Cheng-Ta Li*, Mu-Hong Chen, Chi-Hung Juan, Hsiang-Hsuan Huang, Li-Fen Chen, Jen-Chuen Hsieh, Pei-Chi Tu, Ya-Mei Bai, Shin-Jen Tsai, Ying-Chiao Lee, Tung-Ping Su* (2014). Efficacy of prefrontal theta-burst stimulation in refractory depression: a randomized sham-controlled study. Brain, doi: 10.1093/brain/awu109. [SCI, IF=10.103, RF=0.026 (6/192), CLINICAL NEUROLOGY]

  17. Tai-Ying Liu, Yong-Sheng Chen, Tung-Ping Su, Jen-Chuen Hsieh, Li-Fen Chen* (2014). Abnormal early gamma responses to emotional faces differentiate unipolar from bipolar disorder patients. BioMed Research International. 2014:906104. [SCI, IF=2.134, RF=0.503 (81/161), BIOTECHNOLOGY & APPLIED MICROBIOLOGY]

  18. Cheng-Ta Li, Li-Fen Chen, Pei-Chi Tu, Shyh-Jen Wang, Mu-Hong Chen, Tung-Ping Su, Jen-Chuen Hsieh* (2013). Impaired prefronto-thalamic functional connectivity as a key feature of treatment-resistant depression: a combined MEG, PET and rTMS study. PLoS ONE 8(8): e70089. [SCI, IF=3.057, RF=0.175 (11/63), MULTIDISCIPLINARY SCIENCES]

  19. Hsiao-Ping Shen, Yong-Sheng Chen, Jen-Chuen Hsieh, Tung-Ping Su, and Li-Fen Chen* (2012). Abnormal neural responses to facial rxpression images in major depressive patients. Journal of Neuroscience and Neuroengineering, 1:1-7. [非SCI]

  20. Hui-Ling Chan, Yong-Sheng Chen*, and Li-Fen Chen (2012). Selection of independent components based on cortical mapping of electromagnetic activity. Journal of Neural Engineering, 9(5):056006. [SCI, IF=3.493, RF=0.132 (10/76), ENGINEERING, BIOMEDICAL]

  21. Peichi Tu, Li-Fen Chen, Jen-Chuen Hsieh, Ya-Mei Bai, Cheng-Ta Li, and Tung-Ping Su. (2012). Regional cortical thinning in patients with major depressive disorder: a surface-based morphometry study. Psychiatry Res, 202(3):206-13. [SCI, IF=2.466, RF=0.443 (62/140), PSYCHIATRY]

  22. Tai-Ying Liu, Jen-Chuen Hsieh, Yong-Sheng Chen, Pei-Chi Tu, Tung-Ping Su, and Li-Fen Chen* (2012) Different patterns of abnormal gamma oscillatory activity in unipolar and bipolar disorder patients during an implicit emotion task. Neuropsychologia, 50:1514–1520. [SCI, IF=2.989, RF=0.333 (17/51), BEHAVIORAL SCIENCES]

  23. Jia-Xiu Liu, Yong-Sheng Chen, Jen-Chuen Hsieh, Tung-Ping Su, Tzu-Chen Yeh, and Li-Fen Chen* (2010) Differences in white matter abnormalities between bipolar I and II disorders. Journal of Affective Disorders, 127:309–315. [SCI, IF=3.570, RF=0.234 (45/192), CLINICAL NEUROLOGY]

  24. Cheng-Hao Tu, David M. Niddam, Hsiang-Tai Chao, Li-Fen Chen, Yong-Sheng Chen, Yu-Te Wu, Tzu-Chen Yeh, Jiing-Feng Lirng, and Jen-Chuen Hsieh (2010) Brain morphological changes associated with cyclic menstrual pain. Pain, 150(3):462–468. [SCI, IF=5.557, RF=0.065 (2/31), ANESTHESIOLOGY]

  25. Pin-Shiuan Lee, Yong-Sheng Chen, Jen-Chuen Hsieh, Tung-Ping Su, and Li-Fen Chen* (2010) Distinct neuronal oscillatory responses between patients with bipolar and unipolar disorders: a magnetoencephalographic study. Journal of Affective Disorders, 123:270-275. [SCI, IF=3.570, RF=0.234 (45/192), CLINICAL NEUROLOGY]

  26. Jia-Xiu Liu, Yong-Sheng Chen, and Li-Fen Chen* (2010) Fast and accurate registration techniques for affine and nonrigid alignment of MR brain images. Annals of Biomedical Engineering, 38(1):138-157. [SCI, IF=2.887, RF=0.211 (16/76), ENGINEERING, BIOMEDICAL]

  27. Jia-Xiu Liu, Yong-Sheng Chen, and Li-Fen Chen* (2009) Accurate and robust extraction of brain regions using a deformable model based on radial basis functions. Journal of Neuroscience Methods, 183(2):255–266. [SCI, IF=2.053, RF=0.610 (47/77), BIOCHEMICAL RESEARCH METHODS]

  28. Ren-Jen Hwang, Jen-Chuen Hsieh*, Chi-Hsun Wu, Li-Fen Chen, Tzu-Chen Yeh. (2009) Female menstrual phases modulate human prefrontal asymmetry: a magnetoencephalographic study. Hormones and Behavior, 55:203-209. [SCI, IF= 3.340, RF=0.137 (7/51), BEHAVIORAL SCIENCES]

  29. Lynn Y.L. Shih, Li-Fen Chen, Wen-Jui Kuo, Tzu-Chen Yeh, Yu-Te Wu, Ovid J.L. Tzeng, Jen-Chuen Hsieh*. (2009) Sensory acquisition in the cerebellum: An fMRI study of cerebrocerebellar interaction during visual duration discrimination. Cerebellum, 8(2):116-126. [SCI,IF=2.429, RF=0.594 (152/256), NEUROSCIENCES]

  30. Shyan-Shiou Chen, Pei-Chi Tu, Tung-Ping Su, Jen-Chuen Hsieh, Ying-Chia Lin, Li-Fen Chen* (2008) Impaired frontal synchronization of spontaneous magnetoencephalographic activity in patients with bipolar disorder. Neuroscience Letters, 445(2):174-178. [SCI, IF=2.107, RF=0.668 (171/256), NEUROSCIENCES]

  31. Jia-Xiu Liu, Yong-Sheng Chen, and Li-Fen Chen* (2008) Nonlinear registration based on the approximation of radial basis function coef?cients. Journal of Medical and Biological Engineering, 28(3):127-133. [SCI, IF=1.018, RF=0.724 (55/76), ENGINEERING, BIOMEDICAL]

  32. Yong-Sheng Chen, Li-Fen Chen*, Ya-Ting Chang, Yung-Tien Huang, Tong-Ping Su, Jen-Chuen Hsieh (2008) Quantitative evaluation of brain magnetic resonance images based on voxel-based morphometry and bayesian theorem for patients with bipolar disorder. Journal of Medical and Biological Engineering, 28(3):119-126. [SCI, IF=1.018, RF=0.724 (55/76), ENGINEERING, BIOMEDICAL]

  33. Ren-Jen Hwang, Li-Fen Chen, Tzu-Chen Yeh, Pei-Chi Tu, Chung-Haow Tu, Jen-Chuen Hsieh* (2008) The resting frontal alpha asymmetry across the menstrual cycle: a magnetoencephalographic study. Hormones and Behavior, 54:28–33 [SCI, IF= 3.340, RF=0.137 (7/51), BEHAVIORAL SCIENCES]

  34. Shyan-Shiou Chen, Li-Fen Chen, Yu-Te Wu, Yu-Zu Wu, Po-Lei Lee, Tzu-Chen Yeh, and Jen-Chuen Hsieh (2007) Detection of synchronization between chaotic signals: an Adaptive Similarity Approach. Physical Review E, 76:066201-1~11. [SCI, IF=2.252, RF=0.113 (6/53), PHYSICS, MATHEMATICAL]

  35. Yong-Sheng Chen, Chih-Yu Cheng, Jen-Chuen Hsieh, and Li-Fen Chen* (2006) Maximum contrast beamformer for electromagnetic mapping of brain activity. IEEE Transactions on Biomedical Engineering, 53(9):1765-1774. [SCI, IF=2.468, RF=0.290 (22/76), ENGINEERING, BIOMEDICAL]

  36. Lieber Po-Hung Li, An-Suey Shiao, Li-Fen Chen, David M. Niddam, Shyue-Yih Chang, Chiang-Fen Lien, S. K. Lee, and Jen-Chuen Hsieh* (2006) Healthy-side dominance of middle- and long-latency neuromagnetic fields in idiopathic sudden sensorineural hearing loss. European Journal of Neuroscience, P1–10. [SCI, IF=2.975, RF=0.445 (114/256), NEUROSCIENCES]

  37. Yu-Zu Wu, David M. Niddam, Chun-Chuan Chen, Kwong-Kum Liao, Chou-Ming Cheng, Li-Fen Chen, Po-Lei Lee, Shyan-Shiou Chen, Tzu-ChenYeh, and Jen-Chuen Hsieh* (2006) Effects of cognitive demands on postmovement motor cortical deactivation. NeuroReport, 17(4):371-375. [SCI, IF=1.343, RF=0.856 (219/256), NEUROSCIENCES]

  38. Chih-I Hung, Po-Lei Lee, Yu-Te Wu*, Li-Fen Chen, Tzu-Chen Yeh, Jen-Chuen Hsieh (2005) Recognition of motor imagery electroencephalography using independent component analysis and machine classifiers. Annals of Biomedical Engineering, 33(8):1053-1070. [SCI, IF=2.887, RF=0.211 (16/76), ENGINEERING, BIOMEDICAL]

  39. Yung-Cheng Cheng, Yong-Sheng Chen, Jen-Chuen Hsieh, Li-Fen Chen* (2005) Camera-guided coordinate system alignment for neuromagnetic source estimation. International Journal of Bioelectromagnetism, 7(2):86-89. [Non-SCI]

  40. Hong-Yi Liu, Yong-Sheng Chen*, Li-Fen Chen, and Jen-Chuen Hsieh (2005) Statistical mapping of cortical activities using minimum-variance maximum-discrimination spatial filtering. International Journal of Bioelectromagnetism, 7(2):104-107. [Non-SCI]

  41. David M. Niddam, Li-Fen Chen, Yu-Te Wu, Jen-Chuen Hsieh* (2005) Spatiotemporal brain dynamics in response to muscle stimulation. NeuroImage, 25(3):942-951. [SCI, IF=5.463, RF=0.057 (7/124), RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING]

  42. Ching-Liang Lu, Yu-Te Wu, Tzu-Chen Yeh, Li-Fen Chen, Full-Young Chang, Shou-Dong Lee, Low-Tone Ho, Jen-Chuen Hsieh* (2004) Neuronal correlates of gastric pain induced by fundus distension: a 3T-fMRI study. Neurogastroenterology and Motility, 16(5):575-587. [SCI, IF=3.310, RF=0.297 (57/192), CLINICAL NEUROLOGY]

  43. Wen-Jui Kuo, Tzu-Chen Yeh, Jun-Ren Lee, Li-Fen Chen, Po-Lei Lee, S-S Chen, Low-Tone Ho, Daisy L. Hung, Ovid J.-L Tzeng, Jen-Chuen Hsieh* (2004) Orthographic and phonological processing of Chinese characters: an fMRI study. NeuroImage. 21:1721-1731. [SCI, IF=5.463, RF=0.057 (7/124), RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING]

  44. Po-Lei Lee, Yu-Te Wu, Li-Fen Chen, Yong-Sheng Chen, Chou-Ming Cheng, Tzu-Chen Yeh, Low-Tone Ho, Mau-Song Chang, Jen-Chuen Hsieh* (2003) ICA-based spatiotemporal approach for single-trial analysis of post-movement MEG beta synchronization. NeuroImage, 20:2010-2030. [SCI, IF=5.463, RF=0.057 (7/124), RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING]

  45. Lieber Po-Hung Li, An-Suey Shiao, Yung-Yang Lin, Li-Fen Chen, David M. Niddam, Shyue-Yih Chang, Chiang-Fen Lien, Nan-San Chou, Low-Tone Ho, Jen-Chuen Hsieh* (2003) Healthy-side dominance of cortical neuromagnetic responses in sudden hearing loss. Annals of Neurology, 53:810-815. [SCI, IF=9.638, RF=0.031 (6/192), CLINICAL NEUROLOGY]

  46. Yu-Te Wu, Li-Fen Chen, Hui-Yun Chen, Po-Lei Lee, Tzu-Chen Yeh, Jen-Chuen Hsieh (2003) A wavelet-based approach for color image registration. Journal of Imaging Science and Technology. 47(3):185-199. [SCI, IF=0.316, RF=1 (24/24), IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY]

  47. Yu-Te Wu*, Li-Fen Chen, Po-Lei Lee, Tzu-Chen Yeh, Jen-Chuen Hsieh (2003) Discrete signal matching using coarse-to-fine wavelet basis functions. Pattern Recognition 36: 171-192. [SCI, IF=3.399, RF=0.078 (20/255), ENGINEERING, ELECTRICAL & ELECTRONIC]

  48. Yu-Te Wu*, Hui-Yun Chen, Li-Fen Chen, Po-Lei Lee, Tzu-Chen Yeh, Jen-Chuen Hsieh (2002) Fetal heart tracking in ultrasound image sequences using coarse-to-fine wavelet. Journal of Medical and Biological Engineering, 22(2): 67-74. [SCI, IF=1.018, RF=0.724 (55/76), ENGINEERING, BIOMEDICAL]

  49. Po-Lei Lee, Li-Fen Chen, Yu-Te Wu*, Hsiu-Feng Chiu, Kuo-Kai Shyu, Tzu-Chen Yeh, Jen-Chuen Hsieh (2002) Classifying MEG 20Hz rhythmic signals of left, right index finger movement and resting state using cascaded radial basis function networks. Journal of Medical and Biological Engineering 22(3): 147-152. [SCI, IF=1.018, RF=0.724 (55/76), ENGINEERING, BIOMEDICAL]

  50. Li-Fen Chen, Hong-Yuan Mark Liao, and Ja-Chen Lin (2002) Wavelet-based optical flow estimation. IEEE Transactions on Circuits and Systems for Video Technology 12(1): 1-12. [SCI, IF=2.254, RF=0.212 (54/255), ENGINEERING, ELECTRICAL & ELECTRONIC]

  51. Li-Fen Chen, Hong-Yuan Mark Liao*, Chin-Chuan Han and Ja-Chen Lin (2001) Why recognition in a statistics-based face recognition system should be based on the pure face portion: a probabilistic decision-based proof. Pattern Recognition 34(7): 19-29. [SCI, IF=3.399, RF=0.078 (20/255), ENGINEERING, ELECTRICAL & ELECTRONIC]

  52. Li-Fen Chen, Hong-Yuan Mark Liao*, Ja-Chen Lin, Ming-Tat Ko and Gwo-Jong Yu (2000) A new LDA-based face recognition system which can solve the small sample size problem. Pattern Recognition 33(10): 1713-1726. [SCI, IF=3.399, RF=0.078 (20/255), ENGINEERING, ELECTRICAL & ELECTRONIC]


[Conference Papers]

  1. Pin-Shiuan Lee, Yong-Sheng Chen, Tung-Ping Su, Jen-Chuen Hsieh, Li-Fen Chen* (2015) Identification of patients with unipolar and bipolar disorders using neuromagnetic cortical responses. Poster presented at the 4th Congress of Asian College of Neuropsychopharmacology, Taipei, Taiwan, November 20-22, 2015.

  2. Hui-Ling Chan, Yong-Sheng Chen, Li-Fen Chen*, Sylvain Baillet (2015). Beamformer-based imaging of phase-amplitude coupling using electromagnetic brain activity. Oral presentation and Contributed paper presented at 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Milano, Italy, August 25-29, 2015.

  3. Po-Chih Kuo, Li-Fen Chen, Yong-Sheng Chen* (2015) Manifold representation of brain activity by faces with different orientations using MEG data. Poster presented at the 21th Annual Meeting of the Organization for Human Brain Mapping, Hawaii, USA, June 14-18, 2015.

  4. Pin-Shiuan Lee, Yong-Sheng Chen, Cheng-Hao Tu, Hsiang-Tai Chao, Jen-Chuen Hsieh, Li-Fen Chen* (2015) Neural correlates of resting theta oscillations in primary dysmenorrhea: an MEG study. Poster presented at the 21th Annual Meeting of the Organization for Human Brain Mapping, Hawaii, USA, June 14-18, 2015.

  5. Ching-Ju Yang, Tzu-Yi Hong, Chia-Shu Lin, Tai-Ying Liu, Hsin-Yen Yu, Li-Fen Chen, Jen-Chuen Hsieh* (2015) Brain resilience of neural network of body representation in dancer. Poster presented at the 21th Annual Meeting of the Organization for Human Brain Mapping, Hawaii, USA, June 14-18, 2015.

  6. Chuan-Tao Wang, Chung-Heng Shih, Wen-Yih Isaac Tseng, Hsin-Yen Yu, Jen-Chuen Hsieh and Li-Fen Chen* (2015) White matter plasticity after long-term dancing training revealed by diffusion spectrum imaging. Poster presented at the 21th Annual Meeting of the Organization for Human Brain Mapping, Hawaii, USA, June 14-18, 2015.

  7. Yi-Jung Liu, Tai-Ying Liu, Li-Kai Cheng, Hsin-Yen Yu, Jen-Chuen Hsieh, Li-Fen Chen* (2015) Neuroplasticity of neuromagnetic responses to emotional prosody after long-term musical training. Poster presented at the 21th Annual Meeting of the Organization for Human Brain Mapping, Hawaii, USA, June 14-18, 2015.

  8. Yueh-Hua Chen, Chia-Shu Lin, Lin-Chien Lee, Cheng-Hao Tu, Wei-Chi Li, Li-Fen Chen, Hsiang-Tai Chao, and Jen-Chuen Hsieh* (2015). Unaltered functional brain architecture in primary dysmenorrhea. Poster presented at the 21th Annual Meeting of the Organization for Human Brain Mapping, Hawaii, USA, June 14-18, 2015.

  9. Ting-Hsuan Wu, Cheng-Hao Tu, Wei-Chi Li, Li-Fen Chen, Hsiang-Tai Chao, and Jen-Chuen Hsieh* (2015) Altered intra- and inter-regional functional connectivity in primary dysmenorrhea. Poster presented at the 21th Annual Meeting of the Organization for Human Brain Mapping, Hawaii, USA, June 14-18, 2015.

  10. Shih-Yen Lin, Yong-Sheng Chen*, Li-Fen Chen (2014). A fast and accurate algorithm for diffeomorphic and symmetric non-rigid registration of brain magnetic resonance images. Student paper presented at 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering, Tainan, Taiwan, October 9-12, 2014.

  11. Wei-Chi Li, Cheng-Hao Tu, Hsiang-Tai Chao, Tzu-Chen Yeh, Li-Fen Chen, Jen-Chuen Hsieh (2014) High prevalence of normal variant and abnormality in magnetic resonance imaging of the brains of young primary dysmenorrhic females. Poster presented at 15th World Congress on Pain, Buenos Aires, Argentina, Oct 6-11, 2014.

  12. Shyh-Yuh Wei, Cheng-Hao Tu, Chih-Ying Chuang, Hsiang-Tai Chao, Li-Fen Chen and Jen-Chuen Hsieh (2014) Primary dysmenorrhea is associated with altered intrinsic functional connectivity in periaqueductal grey matter. Poster presented at 15th World Congress on Pain, Buenos Aires, Argentina, Oct 6-11, 2014.

  13. Ting-Yu Chang, Cheng-Ta Li, Chi-Hung Jung, Jen-Chuen Hsieh, Tung-Ping Su, Li-Fen Chen (2014) Neuromodulation by theta-burst stimulation in treatment-resistant major depression: an MEG study. Poster presented at 2014 Annual Congress of Taiwan Society of Biological Psychiatry and Neuropsychopharmacology, Taipei, Taiwan, Sep 20-21, 2014.

  14. Intan Low, Yu-Hsiang Liu, Cheng-Hao Tu, Hsiang-Tai Chao, Jen-Chuen Hsieh, Li-Fen Chen (2014) Long-term cyclic menstrual pain changes emotional prosody processing in primary dysmenorrhea females. Poster presented at the 19th International Conference on Biomagnetism, Halifax, Nova Scotia, Canada, August 24-28, 2014.

  15. Tai-Ying Liu, Li-Kai Cheng, Hsin-Yen Yu, Yong-Sheng Chen, Jen-Chuen Hsieh, Li-Fen Chen (2014) Long-term artistic training modulates alpha oscillations in the inferior frontal gyrus. Poster presented at the 19th International Conference on Biomagnetism, Halifax, Nova Scotia, Canada, August 24-28, 2014.

  16. Pin-Shiuan Lee, Yong-Sheng Chen, Cheng-Hao Tu, Hsiang-Tai Chao, Ming-Wei Lin, Jen-Chuen Hsieh, Li-Fen Chen (2014) Effect of BDNF Val66Met polymorphism on low-alpha/gamma coupling of spontaneous oscillations in primary dysmenorrhea. Poster presented at the 19th International Conference on Biomagnetism, Halifax, Nova Scotia, Canada, August 24-28, 2014.

  17. Chiu-Jung Huang, Cheng-Hao Tu, Tung-Ping Su, Jen-Chuen Hsieh, Li-Fen Chen (2014) Altered Processing of Emotional Conflict in PMDD: a MEG study. Poster presented at the 19th International Conference on Biomagnetism, Halifax, Nova Scotia, Canada, August 24-28, 2014.

  18. Ting-Yu Chang, Cheng-Ta Li, Chi-Hung Jung, Jen-Chuen Hsieh, Tung-Ping Su, Li-Fen Chen (2014) Neuromodulation by theta-burst stimulation in treatment-refractory major depression: an MEG study. Poster presented at 國立陽明大學102學年度學術論文研討會, Taipei, Taiwan, June 13, 2014.

  19. Ruei-Jyun Hung, Yong-Sheng Chen, Jen-Chuen Hsieh, Li-Fen Chen (2014) Neural correlates of positive affect induced by repeated exposure. Poster presented at the 20th Annual Meeting of the Organization for Human Brain Mapping, Hamburg, Germany, June 8-12, 2014.

  20. Pei-Chi Hu, Po-Chih Kuo, Li-Fen Chen, Yong-Sheng Chen (2014) Objective assessment of menstrual pain scale from resting brain signals. Consumer Electronics - Taiwan (ICCE-TW), 2014 IEEE International Conference on, pp.167-168, May 26-28, 2014. doi: 10.1109/ICCE-TW.2014.6904040.

  21. Tai-Ying Liu, Guan-Hua Huang, Cheng-Ta Li, Yong-Sheng Chen, Tung-Ping Su, Jen-Chuen Hsieh, and Li-Fen Chen (2014) Changes in Gray Matter Volumes Induced by Repetitive Transcranial Magnetic Stimulation in Drug-resistant Major Depression. Poster presented at the Joint Annual Meeting ISMRM-ESMRMB, Milan, Italy, May 10-16, 2014.

  22. Li-Fen Chen, Chiu-Jung Huang, Yong-Sheng Chen, Jen-Chuen Hsieh (2014) Common but distinct cortical response to spontaneous and voluntary facial mimicry. Poster presented at 2014 Annual Meeting of Social & Affective Neuroscience Society, Denver, Colorado, USA, April 11-12, 2014.

  23. Wei-Chi Li, Cheng-Hao Tu, Lin-Chien Lee, Hsiang-Tai Chao, Ming-Wei Lin, Li-Fen Chen, Jen-Chuen Hsieh (2014). BDNF Val66Met Polymorphism is Associated with Reduced Hippocampal Volume in Primary Dysmenorrhea. Poster presented at The 2nd Asian Congress on Pain, Taipei, Taiwan, Mar 27-30, 2014.

  24. Chung-Heng Shih, Cheng-Hao Tu, Wei-Chi Li, Hsiang-Tai Chao, Tzu-Chen Yeh, Jen-Chuen Hsieh, Li-Fen Chen (2014). Voxel-based analysis of diffusion tensor images in primary dysmenorrhea. The 2nd Asian Congress on Pain, Taipei, Taiwan, Mar 27-30, 2014.

  25. Li-Fen Chen, Yu-Hsiang Liu, Intan Low, Cheng-Hao Tu, Hsiang-Tai Chao, Ming-Wei Lin, Jen-Chuen Hsieh (2014) Effects of BDNF Val66Met polymorphism on neural responses to emotional prosody in dysmenorrhea: a MEG study. Poster presented at the 11th International Imaging Genetics Conference, UC Irvine, CA, USA, Jan 19-20, 2014.

  26. Ting-Yu Chang, Li-Fen Chen (2014) Investigation of difference between EEG and MEG: an emotional prosody task. Poster presented at 2014 Annual Meeting of Taiwan Society of Cognitive Neuroscience, Jhongli, Taiwan, Jan 18, 2014.

  27. Li-Fen Chen, Yu-Hsiang Liu, Intan Low, Cheng-Hao Tu, Hsiang-Tai Chao, Ming-Wei Lin, Jen-Chuen Hsieh (2014). Effects of BDNF Val66Met polymorphism on neural responses to emotional prosody in dysmenorrhea: a MEG study. Poster presented at 2014 Annual Meeting of Taiwan Society of Cognitive Neuroscience, Jhongli, Taiwan, Jan 18, 2014.

  28. Da-Sih Chuang, Li-Fen Chen (2013) Gender differences in visual-spatial attention: An EEG study. Poster presented at 2013 Annual Symposium on Biomedical Engineering and Technology, HsinChu, Taiwan, Nov 15-16, 2013.

  29. Li-Kai Cheng, Cheng-Hao Tu, Chia-Shu Lin, Li-Fen Chen, Hsiang-Tai Chao, Jen-Chuen Hsieh (2013) Altered Brain Structural Connectivity in Primary Dysmenorrhea. Poster presented at 43rd Annual Meeting of Society for Neuroscience, San Diego, CA, USA, Nov 9-13, 2013.

  30. Wei-Chi Li, Cheng-Hao Tu, Jen-Chuen Hsieh, Li-Fen Chen (2013) Effect of BDNF Val66Met polymorphism on gray matter volume in primary dysmenorrhea. Poster presented at 43rd Annual Meeting of Society for Neuroscience, San Diego, CA, USA, Nov 9-13, 2013.

  31. Tai-Ying Liu, Yong-Sheng Chen, Tung-Ping Su, Jen-Chuen Hsieh, Li-Fen Chen (2013) Abnormal perceptual responses to sad faces in unipolar and bipolar disorders: an MEG study. Poster presented at 19th Annual Meeting of the Organization for Human Brain Mapping, Seattle, WA, USA, June 16-20, 2013.

  32. Pin-Shiuan Lee, Yong-Sheng Chen, Cheng-Hao Tu, Hsiang-Tai Chao, Jen-Chuen Hsieh, Li-Fen Chen (2013) Impaired functional coupling of resting magnetoencephalography in primary dysmenorrhea. Poster presented at 19th Annual Meeting of the Organization for Human Brain Mapping, Seattle, WA, USA, June 16-20, 2013.

  33. Ian-Ting Chu, Cheng-Hao Tu, Hsiang-Tai Chao, Li-Fen Chen, Jen-Chuen Hsieh (2013) Menstrual pain alters the early perceptual processing of emotional prosody. Poster presented at 19th Annual Meeting of the Organization for Human Brain Mapping, Seattle, WA, USA, June 16-20, 2013.

  34. Ruei-Jyun Hung, Li-Fen Chen, Yong-Sheng Chen (2013) Transient phase-locking of parietal responses to repeated faces: Neuroimage evidence of subliminal mere exposure. Poster presented at 20th Cognitive Neuroscience Society, San Francisco, USA, April 13-16, 2013.

  35. Ruei-Jyun Hung, Li-Fen Chen, Yong-Sheng Chen (2013) Transient phase-locking of parietal responses to repeated faces: Neuroimage evidence of subliminal mere exposure. Poster presented at 6th Annual Meeting of Social & Affective Neurodcience Society, San Francisco, USA, April 12-13, 2013.

  36. Lin-Chien Lee, Li-Fen Chen, Intan Low, Cheng-Hao Tu, Horng-Der Shen, Hsiang-Tai Chao, Ming-Wei Lin, Jen-Chuen Hsieh (2013). Brain-derived Neurotrophic Factor Val66Met Polymorphism Modulates the Menstrual Pain Related Depressive and Anxious Moods in Primary Dysmenorrhea. Poster presented at 24th Annual Scientific Meeting of Taiwan Pain Society, Taipei, Taiwan, March 9-10, 2013.

  37. Pin-Shiuan Lee, Yong-Sheng Chen, Jen-Chuen Hsieh, Li-Fen Chen (2012) Dysfunction of cross-frequency phase-phase coupling in primary dysmenorrhea: a resting magnetoencephalographic study. Poster presented at 21st Annual Meeting of Organization for Computational Neuroscience, Decatur, Georgia, USA, July 21-26, 2012.

  38. Mei-Ying Wu, Li-Fen Chen, Tung-Ping Su (2012) Effects of Repetitive Transcranial Magnetic Stimulation Treatment on Emotion Regulation in Major Depression: A MEG Study. 國立陽明大學100學年度學術論文研討會(Poster Presentation), Taiwan, June 16, 2012.

  39. Tai-Ying Liu, Li-Fen Chen, Yong-Sheng Chen, Jen-Chuen Hsieh (2012) Imaging brain dynamics of emotional- perceptual processing by Granger causality analysis: a MEG study. Poster presented at the 18th Annual Meeting of the Organization for Human Brain Mapping, Beijing, China, June 10-14, 2012.

  40. Tung-Ping Su, Li-Fen Chen, Yong-Sheng Chen, Chih-Yu Chan, Pin-Shiuan Lee, Pei-Chi Tu, Jen-Chuen Hsieh (2012) Pattern Classification of Gray Matter Density in Unipolar, Bipolar I, and Bipolar II Patients using Voxel-based Morphometry and Bayesian Classifier. Oral presentation at the 5th Biennial Conference of the International Society for Bipolar Disorders, Istanbul, Turkey, March 14-17, 2012.

  41. Yong-Sheng Chen, Li-Fen Chen, Tzu-Chen Yeh, Jen-Chuen Hsieh, Pin-Shiuan Lee, Kuo-Wei Lee, Yu-Han Shen, Shih-Yen Lin (2011) Pattern Classification of Gray Matter Density in Unipolar, Bipolar I, and Bipolar II Patients using Bayesian Classifier. Poster presented at International Symposium on Clinical Engineering and Medical Informatics, Tainan, Taiwan, Dec. 3, 2011.

  42. Li-Fen Chen, Yong-Sheng Chen, Jen-Chuen Hsieh, Yu-Ying Chou, Chi-Kuang Sun (2011) Dynamic Brain Imaging of Mutual Modulation between Positive Emotion Perception and Cognitive Process (1/3). Poster presented at International Symposium on Clinical Engineering and Medical Informatics, Tainan, Taiwan, Dec. 3, 2011.

  43. Jia-Ping Lin, Yong-Sheng Chen, Li-Fen Chen (2011) Person Identification using Electroencephalographic Signals Evoked by Visual Stimuli. Poster presented at International Conference on Neural Information Processing, Shanghai, China, November 13-17, 2011. Lecture Notes in Computer Science, 7062:684-691.

  44. Chiu-Jung Huang and Li-Fen Chen (2011) Neurophysiological evidence for emotion embodiment. Oral presentation at the 50th Annual Meeting of the Taiwanese Psychological Association, Taichung, Taiwan, Oct. 15-16, 2011.

  45. Yu-Ying Chou, Chi-Kuang Sun, and Li-Fen Chen (2011) Neural correlates of implicit attitudes towards positive and negative emotions. Oral presentation at the 50th Annual Meeting of the Taiwanese Psychological Association, Taichung, Taiwan, Oct. 15-16, 2011.

  46. Hui-Ling Chan, Yong-Sheng Chen, Li-Fen Chen (2011) Maximum Multiple-Correlation Beamformer for Estimating Source Connectivities in Electromagnetic Brain Activities. Proceedings of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, Massachusetts, Aug. 30-Sep. 3, 2011, pp. 5024-5027.

  47. Pin-Shiuan Lee, Li-Fen Chen, Yong-Sheng Chen, Tung-Ping Su, Jen-Chuen Hsieh (2011) Discriminant maps of cortical activity for classification of affective disorders. Poster presented at the 17th Annual Meeting of the Organization on Human Brain Mapping in Québec City, Canada, June 26-30, 2011.

  48. Tai-Ying Liu, Li-Fen Chen, Yong-Sheng Chen, Jen-Chuen Hsieh (2010) Distinct gamma oscillatory responses to different facial images during early visual processing: an MEG study. Poster presented at Annual Symposium of Biomedical Engineering, Kaohsiung, Taiwan, Dec. 10-11 2010.

  49. Tzu-han Hu, Li-Fen Chen, Tung-Ping Su, Jen-Chuen Hsieh (2010) Pattern classification of resting oscillatory neuromagnetic activity among patients with mood disorder. Poster presented at 2010 Annual Symposium of Biomedical Engineering, Kaohsiung, Taiwan, Dec. 10-11, 2010.

  50. Chi-Kuang Sun, Yu-Ying Chou, Li-Fen Chen (2010) Neural correlates of implicit attitudes towards positive and negative emotions. Poster presented at 2010 Social and Affective Neuroscience Conference, Chicago, IL, Oct. 29-31 2010.

  51. Hsin-Fang Lee, Li-Fen Chen, Chang-Hung Lin, Yong-Sheng Chen (2010) Comparison of subjective Epworth Sleepiness Scale with objective polysomnographic evidences. Poster presented at the 20th Congress of the European Sleep Research Society, Lisbon, Portugal, Sep. 14-18, 2010.

  52. Chang-Hung Lin, Yong-Sheng Chen, Yu-Shiuan Yen, Li-Fen Chen (2010) High correlation between sleep disorders and driving safety in Taiwan. Poster presented at the 20th Congress of the European Sleep Research Society, Lisbon, Portugal, Sep. 14-18, 2010.

  53. Hsu-Ping Tuan, Tung-Ping Su, Jen-Chuen Hsieh, Li-Fen Chen (2010) A 3-Month Follow-Up Magnetoencephalographic Study of Repetitive Transcranial Magnetic Stimulation in Major Depression. Poster presented at 16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona, Spain, June 6-10, 2010.

  54. Yu-Chen Lan, Li-Fen Chen, and Jen-Chuen Hsieh (2010) Film-induced positive emotions modulate pain perception and pain related emotions. Poster presented at 16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona, Spain, June 6-10, 2010.

  55. Li-Fen Chen, Tai-Ying Liu, Yong-Sheng Chen, Jen-Chuen Hsieh (2010) Different gamma oscillation patterns for angry facial expressions in MDD and NC during early visual processing: an MEG study. The 16th Annual Meeting of the Organization for Human Brain Mapping 2010, Barcelona, Spain, June 6-10, 2010.

  56. Liang-Wei Chen, Yong-Sheng Chen, and Li-Fen Chen (2009) Three-choice brain-computer interface system through classification and voting of temporal features. Proceedings of 2009 CACS International Automatic Control Conference, Taipei, Taiwan, Nov 27-29, 2009.

  57. Tai-Ying Liu, Li-Fen Chen, Yong-Sheng Chen, Jen-Chuen Hsieh, Tung-Ping Su (2009) Different patterns of abnormal gamma oscillations in bipolar and unipolar disorder patients. Poster presented at the 1st Meeting of the Asian College of Neuropsychopharmacology (AsCNP), Kyoto, Japan, Nov. 13-14, 2009.

  58. Yong-Sheng Chen, Li-Fen Chen, Tung-Ping Su, Jen-Chuen Hsieh, Kui-Han Lin (2009) Structural differences of gray matter between patients with unipolar and bipolar disorders assessed by voxel-based morphometric analysis. Poster presented at the 9th World Congress of Biological Psychiatry, Paris, France, Jun. 28-Jul. 2, 2009.

  59. Yu-Shiuan Yen, Li-Fen Chen, Yong-Sheng Chen, Jen-Chuen Hsieh (2009) Gender effects on neuronal dynamics underlying emotion regulation in the limbic and prefrontal cortex. Poster presented at the 15th Annual Meeting of the Organization for Human Brain Mapping, San Francisco, CA, Jun. 18-23, 2009.

  60. I-Tzu Chen, Yong-Sheng Chen, Li-Fen Chen (2009) Beamformer-based spatiotemporal imaging of correlated brain activities. Proceedings of the Ninth IEEE International Conference on Bioinformatics and Bioengineering, Taichung, Taiwan, Jun 22-24, 2009, pp. 431-434.

  61. Yu-Hsun Lee, Yong-Sheng Chen, Li-Fen Chen (2009) Automated sleep staging using single EEG channel for REM sleep deprivation. Proceedings of the Ninth IEEE International Conference on Bioinformatics and Bioengineering, Taichung, Taiwan, Jun. 2009, pp. 439-442.

  62. Huiling Chan, Yong-Sheng Chen, Li-Fen Chen, Tzu-Hua Chen, I-Tzu Chen (2009) Lead Field Space Projection for Spatiotemporal Imaging of Independent Brain Activities. Proceedings of the 6th International Symposium on Neural Networks, Wuhan during May 26-29, 2009.

[Domestic Patent]

  • Jen-Chuen Hsieh, Tzu-Chen Yeh, Yu-Te Wu, Po-Lei Lee, Li-Fen Chen (2008) Method and Apparatus for Visual derive control. US Patent No.7338171 B2, 2008/03/04~2022/12/31.

[International Patent]

  • 謝仁俊、葉子成、吳育德、李柏磊、陳麗芬、陳永昇, “視覺驅動控制系統及其控制方法,” 中華民國專利 第591481 號, 2004 年 6 月 11 日.

  • 謝仁俊、葉子成、吳育德、李柏磊、陳麗芬、陳永昇, “System and Method for Classification of EEG Signal and EEG-driven Human-computer Interface,”中華民國專利第274269號, 2007/02/21~2022/12/01.






 


 
 

 

 

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