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CURRICULUM VITAE


Jin-Wu Tsai, Ph.D.
Associate Professor, Principle Investigator

Institute of Brain Science
School of Medicine
National Yang-Ming University
155 Li-Nong St. Sec. 2, Beitou 112, Taipei, Taiwan
Tel: +886-2-2826-7305
Fax: +886-2-2827-3123
E-mail: tsaijw@ym.edu.tw
http://bml.ym.edu.tw/ibs/brain/TsaiLab/

APPOINTMENTS:

  • 2018-present: Associate Professor, Institute of Brain Science, School of Medicine, National Yang-Ming University
  • 2012-2018: Assistant Professor, Institute of Brain Science, School of Medicine, National Yang-Ming University
  • 2010-2012: Scientific Manager, Department of Biomedical Imaging, Early Research and Development, Genentech Inc.
  • 2009-2010: Postdoctoral Scholar, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco (UCSF)
  • 2008-2009: Postdoctoral Fellow, Skirball Institute of Biomolecular Medicine, New York University (NYU) Langone Medical Center, New York

EDUCATION:

RESEARCH INTERESTS AND SPECIALTIES:

  • Physics: General optics, Laser optics, Two-photon microscopy, Confocal microscopy, Fluorescence lifetime imaging microscopy (FLIM), Light microscopy
  • Biology: Neural development, Stem cell biology, Neural degenerative diseases, Alzheimer's disease, In utero electroporation, Stroke, Tramatic brain injury, Cell and brain slice culture, Live cell imaging
  • Computer: Digital image process and analysis, Computer programming (MatLab), Web design

HONORS:

  • 2015-2018: Medical Student-Elected Excellent Teaching Award, NYMU School of Medicine
  • 2017: Outstanding Young Investigator Grant, Ministry of Science and Technology, Taiwan
  • 2015: Excellent Teaching Award, National Yang-Ming University
  • 2014: Outstanding Young Investigator Grant, Ministry of Science and Technology, Taiwan
  • 2011: Recognition Award, Genentech Inc.
  • 2011: Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows, National Institutes of Health, USA
  • 2010:"Study Abroad" Postdoctoral Fellowship, National Science Council, Taiwan
  • 2008: Spinal Cord Injury Research Program Postdoctoral Fellowship Award, Spinal Cord Injury Research Board (SCIRB), New York State Department of Health
  • 2008: The Rover Award for Outstanding Achievement in Anatomy and Cell Biology
  • 2008: Ph.D. degree with Distinction, Columbia University
  • 2007: International Brain Research Organization Travel Grant for the World Congress of Neuroscience
  • 2007: The British Council Stem Cell Workshop Scholarship
  • 2006: AAAS/Science Program for Excellence in Science
  • 2006: NIH National Graduate Student Research Festival Scholarship
  • 2006: Taiwanese Bioscientist Association Student Travel Award
  • 2005: The Brunie Prize in Neural Stem Cell Research
  • 2005: American Society for Cell Biology (ASCB) Predoctoral Student Travel Award
  • 2000: The Best Student Paper Award, International Society for Optical Engineering
  • 2000: Outstanding Thesis Award, National Yang-Ming University
  • 1998: Wu Chien-Shiung Science Award, Wu Chien-Shiung Education Foundation
  • 1997: Undergraduate Summer Research Grant, National Science Council, Taiwan
  • 1996, 1994: Presidential Award, National Taiwan University
  • 1994: Scholarship for Talented Students in Mathematics and Natural Sciences, Ministry of Education, Taiwan
  • 1994: The 25th International Physics Olympiad contestant
  • 1994: The 6th Asian Pacific Mathematics Olympiad contestant

INVITED PRESENTATIONS:

  • Invited symposium speaker in the 14th Meeting of the Asian-Pacific Society for Neurochemistry (APSN), Kuala Lumpur, Malaysia (2016)
  • Invited speaker in Focus on Microscopy 2016 conference , Taipei, Taiwan (2016)
    Invited symposium speaker in the 6th Federation of Asia-Oceanian Neuroscience Society (FAONS) Congress and the 11th Biennial Conference of CNS, Wuzhen, China (2015)
  • Invited speaker in the 25th ISN-APSN-ASN Joint Meeting Satellite Meeting, Cairns, Australia (2015)
  • Invited speaker in the 4th Symposium of World Association of Chinese Epileptologists (WACE), Kaohsiung, Taiwan (2014)
  • Invited speaker in the 4th Annual World Congress of Molecular & Cell Biology Meeting, Dalian, China (2014)
  • Invited speaker in the 12th Annual Meeting of the Taiwan Epilepsy Society, Taipei, Taiwan (2014)
  • 2013: Invited speaker in the Conference of the Federation of Asian Societies for Molecular Imaging, Taipei, Taiwan
  • 2013: Invited speaker in the Combined ASBMB, ASPS, and ANZSCDB Annual Meeting (ComBio), Perth, Australia
  • 2013: Invited speaker in the International Symposium on Development, Morphogenesis, and Stem Cells, Taipei, Taiwan
  • 2012: Invited speaker in the 6th NYMU-UCSD Bilateral Symposium, La Jolla, CA
  • 2011: Invited speaker in the Annual Meeting of Taiwan Neuroscience Society, Taipei, Taiwan
    2010: Invited speaker in the 4th NYMU-UCSD Bilateral Symposium, La Jolla, CA
  • 2009: Speaker in the 39th Neuroscience Meeting, Chicago, IL, Society for Neuroscience
  • 2009: Invited speaker in the 2nd Global COE Retreat, Hokuto, Japan, University of Tokyo
  • 2008: Invited speaker in the 1st Tohoku Neuroscience GCOE conference "From Genes to Development and Behavior", Zao, Japan, Tohoku University
  • 2007: Speaker in the "Stem cells, axon guidance and migration in the developing and adult brain" conference, Cairns, Australia, IBRO
  • 2006: Invited speaker in the 46th Cell Biology Meeting, San Diego, CA, ASCB
  • 2006: Invited speaker in the CAS Symposium on Model Organisms and Diseases, Beijing, China, Chinese Academy of Sciences
  • 2006: Speaker in the 36th Neuroscience Meeting, Atlanta, GA, Society for Neuroscience
  • 2005: Speaker in the 35th Neuroscience Meeting, Washington, DC, Society for Neuroscience
  • 2004: Invited speaker in the 44th Cell Biology Meeting, Washington, DC, ASCB
  • 2000: Invited speaker in Photonics Taiwan 2000, Taipei, Taiwan, Int'l Society of Optical Engineering

PATENTS:

  1. Chi-Hung Lin, Jin-Wu Tsai and Yong-Shyang Yi. "Cell Observing Method and the System Thereof" Patent of the Republic of China #00594011 (2004-2020)

PUBLICATIONS:

  1. Nian FS, Li LL, Cheng CY, Wu PC, Lin YT, Tang CY, Ren BS, Tai CY, Fann MJ, Kao LS, Hong CJ, Tsai JW* (2019) Rab18 collaborates with Rab7 to modulate lysosomal and autophagy activities in the nervous system: An overlapping mechanism for Warburg micro syndrome and Charcot-Marie-Tooth neuropathy type 2B. Mol Neurobiol, accepted. (* corresponding)

  2. Chang CH, Zanini M, Shirvani H, Cheng JS, Yu H, Feng CH, Mercier AL, Hung SY, Forget A, Wang CH, Cigna SM, Lu IL, Chen WY, Leboucher S, Wang WJ, Ruat M, Spassky N, Tsai JW*, Ayrault O* (2019) Atoh1 requires primary cilia for the expansion of granule neuron progenitors by modulating centriolar satellites. Dev Cell, accepted. (* corresponding)

  3. Chen JL, Chang CH, Tsai JW* (2019) Gli2 rescues delays in brain development induced by Kif3a dysfunction. Cereb Cortex, 29(2):751-64. (* corresponding)

  4. Hsiao CJ, Chang CH, Ibrahim RB, Lin IH, Wang CH, Wang WJ, and Tsai JW* (2018) Gli2 modulates cell cycle re-entry through autophagy-mediated regulation on the length of primary cilia. J Cell Sci, 131(24). pii: jcs221218. (* corresponding)

  5. Kilander MBC, Wang CH, Chang CH, Nestor JE, Herold K, Tsai JW, Nestor MW, Lin YC (2018) A rare human CEP290 variant disrupts the molecular integrity of the primary cilium and impairs Sonic Hedgehog machinery. Sci Rep, 8(1):17335.

  6. Chen YA, Lu IL, Tsai JW* (2018) Contactin-1/F3 regulates neuronal migration and morphogenesis through modulating RhoA activity. Front Mol Neurosci, 11:422. (* corresponding)

  7. Lu IL, Chen C, Tung CY, Chen HH, Pan JP, Chang CH, Cheng JS, Chen YA, Wang CH, Huang CW, Kang YN, Chang HY, Li LL, Chang KP, Shih YH, Lin CH, Kwan SY, Tsai JW* (2018) Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice. Nat Commun, 9(1):2498. (* corresponding)

  8. Valente P, Romei A, Fadda M, Sterlini B, Lonardoni D, Forte N, Fruscione F, Castroflorio E, Michetti C, Giansante G, Valtorta F, Tsai JW, Zara F, Nieus T, Corradi A, Fassio A, Baldelli P, Benfenati F (2018) Constitutive inactivation of the PRRT2 gene alters short-term synaptic plasticity and promotes network hyperexcitability in hippocampal neurons. Cereb Cortex, in press.

  9. Jheng GW, Hur SS, Chang CM, Wu CC, Cheng JS, Lee HH, Chung BC, Wang YK, Lin KH, del ?lamo JC, Chien S, Tsai JW* (2018). Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration. Biochem Biophys Res Commun, 497, 869-75. (* corresponding)

  10. Chakraborty S, Karmenyan A, Tsai JW, Chiou A (2017) Inhibitory effects of curcumin and cyclocurcumin in 1-methyl-4-phenylpyridinium (MPP+) induced neurotoxicity in differentiated PC12 cells. Sci Rep, 7, 16977.

  11. Liu YH, Tsai JW, Chen JL, Yang WS, Chang PC, Cheng PL, Turner DL, Yanagawa Y, Wang TW, Yu JY (2017) Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon. Sci Rep, 7, 42895.

  12. Chen HR, Juan HC, Wong YH, Tsai JW, Fann MJ (2016) Cdk12 regulates neurogenesis and late-arising neuronal migration in the developing cerebral cortex. Cereb Cortex, 27:2289-302.

  13. Liu YT, Nian FS, Chou WJ, Tai CY, Kwan SY, Chen C, Kuo PW, Lin PH, Chen CY, Huang CW, Lee YC, Soong BW*, Tsai JW* (2016) PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental defects. Oncotarget, 7, 39184-96. (* corresponding)

  14. Tsai MH, Kuo PW, Myers CT, Li SW, Lin WJ, Fu TY, Chang HY, Mefford HC, Chang YC*, Tsai JW* (2016). A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies. Eur J Paediatr Neurol, 20, 788-94. (* corresponding)

  15. Chakraborty S, Nian FS, Tsai JW, Karmenyan A, Chiou A (2016) Quantification of the metabolic state in cell-model of Parkinson's disease by fluorescence lifetime imaging microscopy. Sci Rep, 6, 19145.

  16. Ma L*, Qiao Q*, Tsai JW*, Yang G, Li W, Gan WB (2016) Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex. Dev Neurobiol, 76, 277-286. (*equal contribution)

  17. Qiao Q, Ma L, Li W, Tsai JW, Yang G, Gan WB (2016) Long-term stability of axonal boutons in the mouse barrel cortex. Dev Neurobiol, 76, 252-261.

  18. Cheng CY, Wu JC, Tsai JW, Nian FS, Wu PC, Kao LS, Fann MJ, Tsai SJ, Liou YJ, Tai CY, Hong CJ (2015) ENU mutagenesis identifies mice modeling Warburg Micro syndrome with sensory axon degeneration caused by a deletion in Rab18. Exp Neurol, 267, 143-151.

  19. Tsai JW & Vallee RB (2011) Live microscopy of neural stem cell migration in brain slices. Methods Mol Biol, 750:131-42.

  20. Wang X, Tsai JW, Lamonica B & Kriegstein AR (2011) A new subtype of progenitor cell in the mouse embryonic neocortex. Nat Neurosci, 14, 555-561. (Cover; featured in News and Views)

  21. Tsai JW*, Lian WN*, Kemal SK, Kriegstein AR & Vallee RB (2010) Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells. Nat Neurosci, 13, 1463-1471. (*equal contribution)

  22. Wang X, Tsai JW, Imai JH, Lian WN, Vallee RB & Shi SH (2009) Asymmetric inheritance of centrosome maintains neural progenitors during mammalian neocortical neurogenesis. Nature 461, 947-955. (Cover; featured in News and Views)

  23. Vallee RB, Seale GE & Tsai JW (2009) Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones. Trends Cell Biol 19, 347-355.

  24. Tsai JW , Bremner KH & Vallee RB. Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue. Nat Neurosci 10, 970-979 (2007).

  25. Richard B. Vallee and Jin-Wu Tsai. The Cellular Roles of the Lissencephaly Gene LIS1, and What They Tell Us About Brain Development. Genes & Development 20, 1384-1393 (2006). (Perspective)

  26. Jin-Wu Tsai, Yu Chen, Arnold R. Kriegstein, and Richard B. Vallee. LIS1 RNAi blocks neural Stem cell division, morphogenesis, and motility at multiple stages. The Journal of Cell Biology 170, 935-945 (2005). (Journal cover and highlight paper)

  27. Chia-Fen Hsieh, Bo-Jui Chang, Chyi-Huey Pai, Hsuan-Yi Chen, Jin-Wu Tsai, Yung-Hsiang Yi, Yi-Ting Chiang, Da-Wei Wang, Sien Chi, Long Hsu, and Chi-Hung Lin. Stepped changes of monovalent ligand-binding force during ligand-induced clustering of integrin aIIbb3. The Journal of Biological Chemistry 281, 25466-25474 (2006).

  28. Chia-Fen Hsieh, Bo-Jui Chang, Chyi-Huey Pai, Hsuan-Yi Chen, Sien Chi, Long Hsu, Jin-Wu Tsai, and Chi-Hung Lin. Identification of stepped changes of binding affinity during interactions between the disintegrin rhodostomin and integrin aIIbbIII in living cells using optical tweezers. Proceedings of SPIE 5514, 215-224 (2004).

  29. Jen-Chang Liu, Wen-Liang Hwang, Ming-Syan Chen, Jin-Wu Tsai, and Chi-Hung Lin. Wavelet-based Active Contour Model for Object Tracking. ICIP Proceedings 3, 206-209 (2001).

  30. Chi-Hung Lin and Jin-Wu Tsai. [Applications of optical tweezers in biological force measurements.] Physics Bimonthly 22, 500-505 (2000). (Chinese)

  31. Jin-Wu Tsai, Bing-Yao Liao, Chun-Cheng Huang, Wen-Liang Hwang, Da-Wei Wang, Arthur E. Chiou, and Chi-Hung Lin. Applications of optical tweezers and an integrated force measurement module for biomedical research. Proceedings of SPIE 4082, 213-221 (2000). (Best Student Paper Award)

  32. Wei-Nan Lian, Jin-Wu Tsai, Pang-Mien Yu, Tzu-Wei Wu, Shun-Chun Yang, Yat-Pang Chau, and Chi-Hung Lin. Targeting of aminopeptidase N to bile canaliculi correlates with secretory activities of the developing canalicular domain. Hepatology 30, 748-760 (1999).

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CONFERENCE ABSTRACTS:

  1. Tsai JW, Hedehus M, Kallop D, Weimer R. An interactive semi-automatic dendritic spine detection tool for efficient quantification of synaptic dynamics in vivo. Imaging in 2020 VII, Jackson Hole, WY (2011)
  2. Wang X, Tsai JW, Lamonica B, Kriegstein AR. The cellular roles for MCPH genes CDK5RAP2 and CPAP in cortical development. ISSCR 8th Annual Meeting, San Francisco, CA (2010)
  3. Lian WN, Tsai JW & Vallee RB. Cytoplasmic dynein and nonconventional kinesin responsible for bidirectional interkinetic nuclear oscillations in neuroepithelial cells. The 39th Neuroscience Meeting, Chicago, IL (2009)
  4. Tsai JW. From neurogenesis to synaptical genesis: a long journey for cortical neurons. The 2nd Global COE Retreat, Hokuto, Japan (2009)
  5. Tsai JW, Lian WN & Vallee RB. The molecular basis for interkinetic nuclear oscillations in the mammalian neuroepithelium. The 48th Cell Biology Meeting, San Francisco, CA (2008)
  6. Tsai JW, Bremner KH & Vallee RB. Subcellular roles for LIS1 and dynein in radial migration of neurons during embryonic cortical development. The 1st Tohoku Neuroscience Global-COE Conference, Zao, Japan (2008)
  7. Tsai JW, Bremner KH & Vallee RB. Dynein and LIS1 Transport the entire microtubule cytoskeleton through in migrating neural precursors, and myosin IIb brings up the rear. The 47th Cell Biology Meeting, Washington, DC (2007)
  8. Tsai JW & Vallee RB. Dual subcellular roles for lis1 and dynein in radial migration of neurons during embryonic cortical development. IBRO World Congress of Neuroscience, Melbourne, Australia (2007)
  9. Jin-Wu Tsai, Richard B. Vallee. Triple labeling of migrating neural progenitor cells in live brain tissue reveals novel roles for cytoplasmic dynein and LIS1 in centrosomal, nuclear, and microtubule behavior. The 46th Cell Biology Meeting, San Diego, CA (2006)
  10. Jin-Wu Tsai, Richard B. Vallee. Direct observation of microtubule dynamics in live brain tissue. The 46th Cell Biology Meeting, San Diego, CA (2006)
  11. Jin-Wu Tsai, Richard B. Vallee. Triple labeling of neural progenitor cells in live brain tissue reveals novel roles for cytoplasmic dynein and LIS1 in centrosomal and nuclear behavior. The 36th Neuroscience Meeting, Atlanta, GA (2006)
  12. Jin-Wu Tsai, Yu Chen, Arnold R. Kriegstein, and Richard B. Vallee. Multiple effects of LIS1 RNAi on neural progenitor cell division, polarization, axonogenesis, and motility. The 45th Cell Biology Meeting, San Francisco (2005).
  13. Serena C. Tan, Jin-Wu Tsai, Garrett Seale, and Richard B. Vallee. Dynein light intermediate chains: A comparison of distribution and function in fibroblasts and developing neurons. The 45th Cell Biology Meeting, San Francisco, CA (2005).
  14. Jin-Wu Tsai, Yu Chen, Peter Canoll, Arnold R. Kriegstein, and Richard B. Vallee. LIS1 RNAi blocks neural progenitor cells at multiple stages in the radial migration pathway. The 35th Neuroscience Meeting, Washington, DC (2005).
  15. Richard B. Vallee and Jin-Wu Tsai. Role of cytoplasmic dynein and LIS1 in neural progenitor cell migration and division. International Dynein Workshop, Kobe, Japan (2005).
  16. Richard B. Vallee and Jin-Wu Tsai. Role of cytoplasmic dynein in brain developmental and neurodegerative disease. Experimental Biology Conference, San Diego, CA (2005).
  17. Jin-Wu Tsai, Yu Chen, Richard B. Vallee, and Arnold R. Kriegstein. Interference with LIS1 and dynactin arrests neuronal migration at the multipolar stage and interferes with neocortial expansion. Mol. Biol. Cell 15, 173a (2004).
  18. Yong-Shyang Yi, Jin-Wu Tsai, Chi-Hung Lin, and Szecheng J. Lo. Platelet and CHO cell adhesion and morphological change on various recombinant substrates. Mol. Biol. Cell 10, 62a (1999).
  19. CS Yang, WN Lian, YJ Chen, TW Wu, PM Yu, JW Tsai, and CH Lin. Delivery of aminopeptidase N to bile canaliculi correlates with specific transcytosis activities in human hepatoma cell lines. Mol. Biol. Cell 9, 91a (1998).

PROFESSIONAL SOCIETIES:



Updated 02/07/2014. Copyright© 2014 Jin-Wu Tsai. All rights reserved.