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Education
- 2002 Ph.D.
in Electrical Engineering, National
Taiwan University, Taiwan, R.O.C.
Thesis Title: MRI of Neural Fiber
Architecture Based on Diffusion
Anisotropy
- 1993 M.S.
in Biomedical Engineering, National
Yang-Ming University, Taiwan,
R.O.C.
- 1991 B.A.
in Physics, National Central University,
Taiwan, R.O.C.
Award/Honors
- 2007 One of
the ten potential press releases
for the OHBM 2007 Annual Meeting
in Chicago, USA
- 2002 Hsu-Jun
Outstanding Paper Award, The Radiological
Society of the Republic of China,
Taiwan Member of the Phi Tau Phi
Scholastic Honor Society of the
Republic of China
- 2001 Outstanding
Poster Award, Conference on Biomedical
Engineering Technology, Taipei,
Taiwan
- 2000 Outstanding
Poster Award, Conference on Biomedical
Engineering Technology, Taipei,
Taiwan
Editorial Board and
Reviewer
- NeuroImage
- IEEE Transactions
on Medical Imaging
- International Journal
of Biomedical Imaging
- Biomedical Engineering:
Applications, Basis and Communications
- Journal of
Medical and Biological Engineering
Lab Introduction
This laboratory develops
and applies diffusion MRI techniques
to interdisciplinary researches,
including psychology, physiology,
and medicine applications. In technique
development, we develop fiber tracking
techniques of different diffusion
MRI technique such as diffusion
spectrum imaging, which can give
detail information of microstructure.
We also develop, validate, optimize,
and visualize new diffusion imaging
methods. Besides, fundaments of
diffusion MRI related to tissue
microstructure can be clarified
progressively in present researches.
More detail understanding makes
MRI or diffusion MRI feasible for
more applications, such as myelin
degeneration. In psychology, we
integrate several modalities such
as MRI, MEG, and EEG to explore
brain functions while different
reactions or behaviors happen. MRI
can provide high resolution anatomical
images and also show the microstructure
using diffusion techniques. The
temporal information can be obtained
with MEG or EEG, which shows signal
transmission under specific stimulus.
By integrating our neural tractography
with different neuroimages, knowledge
of functional connectivity between
brain neural histoarchitecture can
be revealed. In physiology, we use
diffusion MRI techniques to reveal
tissue structure such as cerebral
neuronal tracts, and some deep nucleus.
Using diffusion quantitative indices,
fractional anisotropy (FA) and apparent
diffusion coefficient (ADC), we
correlate these indices with psychometrics
and their correspondence to some
abnormalities. It is very helpful
to identify abnormal brain regions
as well as functional correlation
in vivo. In medicine applications,
diffusion MRI is exploited to pre-diagnose
and to predict the recovery before
and after operation of brain tumor.
With inter-group comparison between
normal subjects and patients, we
can easily reveal the changes of
schizophrenia, bipolar disorder,
ADHD, and autism patients which
can just be diagnosed by psychometrics
and doctor’s experience. We also
apply diffusion MRI on research
of stroke using rat. Diffusion MRI
can enhance the contrast of different
level of stroke and is helpful to
the researches of trauma. More researches
in our lab are also in progress,
such as automatic segmentation of
the brain, mapping fiber density
by diffusion MRI, correlation between
reaction-time and specific neural
tracts, 3D virtual reality, and
so on.
Publications
International
Journal Papers
1. Chun-Hung Yeh, J.-Donald
Tournier, Kuan-Hung Cho, Ching-Po
Lin*, Fernando Calamante,
Alan Connelly. 2010 “The Effect
of Finite Diffusion Gradient Pulse
Duration on Fibre Orientation Estimation
in Diffusion MRI” NeuroImage (In
press)
2. Yawei Cheng, Chen-Yi
Chen, Ching-Po
Lin, Kun-Hsien Chou, Jean
Decety. 2010 “Love hurts: an fMRI
study” NeuroImage (In press)
3. B. B. Biswal, M.
Mennes, X. Zuo, S. Gohel, C. Kelly,
S. M. Smith, C. F. Beckmann, J.
S. Adelstein, R. L. Buckner, S.
Colcombe, A. Dogonowski, M. Ernst,
D. Fair, M. Hampson, M. J. Hoptman,
J. S. Hyde, V. J. Kiviniemi, R.
Kotter, S. Li, C.
P. Lin, M. J. Lowe, C. Mackay,
D. J. Madden, K. H. Madsen, D. S.
Margulies, H. S. Mayberg, K. McMahon,
C. S. Monk, S. H. Mostofsky, B.
J. Nagel, J. J. Pekar, S. J. Peltier,
S. E. Petersen, V. Riedl, S. A.
Rombouts, B. Rypma, B. L. Schlaggar,
S. S. Seidler, G. J. Siegle, C.
Sorg, G. Teng, J. Veijola, A. Villringer,
M. Walter, L. Wang, X. Weng, S.
Whitfield-Gabrieli, P. Williamson,
C. Windischberger, Y. Zang, H. Zhang,
F. X. Castellanos, M. P. Milham,
2010 “Towards discovery science
of human brain function” Proceedings
of the National Academy of Sciences
(In press)
4. Yawei Cheng, Kun-Hsien
Chou, I-Yun Chen, Yang-Teng Fan,
Jean Decety, Ching-Po
Lin*. 2010 “Atypical Development
of Frontal Fractional Anisotropy
in Adolescents with Autism Spectrum
Disorder” NeuroImage, Apr; 50(3):
873-882
5. Erick Jorge Canales-Rodriguez?,
Ching-Po Lin?, Yasser Iturria-Medina,
Chun-Hung Yeh, Kuan-Hung Cho, Lester
Melie-Garcia 2010 “Diffusion Orientation
Transform Revisited” NeuroImage,
Jan 15; 49(2): 1326-39
6. Cheng-Ta Li, Ching-Po
Lin*, Kun-Hsien Chou, I-Yun
Chen, Jen-Chuen Hsieh, Chia-Liang
Wu, Wei-Chen Lin, Tung-Ping Su*.
2010 “Structural and cognitive deficits
in remitted and non-remitted recurrent
depression: A voxel based morphometric
study” NeuroImage, 50: 347–356
7. Yi-Ping Chao, Kuan-Hung
Cho, Chun-Hung Yeh, Kun-Hsien Chou,
Jyh-Horng Chen, Ching-Po
Lin*. 2009 “Probabilistic
topography of human corpus callosum
using cytoarchitectural parcellation
and HARDI-tractography” Human Brain
Mapping, Oct; 30(10): 3172-87
8. Kuan-Hung Cho,
Chun-Hung Yeh, Jyh-Horng Chen, Ching-Po
Lin*. 2009 “Potential in
reducing scan times of HARDI by
accurate correction of the cross-term
in a hemi-spherical encoding scheme”
Journal of Magnetic Resonance Imaging,
Jun; 29(6): 1386-94
9. Wei-Che Lin, Cheng-Hsien
Lu, Yu-Chang Lee, Hung-Chen Wang,
Chun-Chung Lui, Yu-Fan Cheng, Yi-Ting
Shih, Ching-Po
Lin*. 2009 “White matter
damage in carbon monoxide intoxication
assessed in vivo using diffusion
tensor MRI” American Journal of
Neuroradiology, Jun; 30(6): 1248-55
10. Wei-Ta Chen, Shuu-Jiun
Wang, Jong-Ling Fuh, Ching-Po Lin,
Yu-Chieh Ko, Yung-Yang Lin. 2009
“Peri-ictal Normalization of Visual
Cortex Excitability in Migraine:
an MEG Study” Cephalalgia, 29: 1202-1211
11. Xiujuan Geng,
Thomas J. Ross, Wang Zhan, Hong
Gu, Yi-Ping Chao,
Ching-Po Lin, Gary E. Christensen,
Norbert Schuff, Yihong Yang. 2009
“Diffusion MRI registration using
orientation distribution functions”
Inf Process Med Imaging 21: 626-37.
12. Yu-Ming Chuang,
Ching-Po Lin,
Ho-Fai Wong, Yeu-Jhy Chang, Chien-Hung
Chang, Ting-Yu Chang, Tai-Cheng
Wu, Hsiu-Chuan Wu, Tsong-Hai Lee.
2009 “Plasticity of Circle of Willis:
A longitudinal Observation of Flow
Patterns in the circle of Willis
One Week After Stenting for Severe
Internal Carotid Artery Stenosis”
Cerebrovascular Diseases, Apr 24;
27(6): 572-578
13. Yu-Ming Chuang,
Chien-Chih Chen, Ching-Po
Lin. 2009 “Vertebral artery
hypoplasia may contribute to abnormal
vestibular evoked myogenic potential”
Acta Neurol Taiwan, Jun; 18(2):
113-7
14. Ya Mei Bai, Kun-Hsien
Chou, Ching-Po
Lin*, I-Yun Chen, Cheng-Ta
Li, Yang Kai Chun, Tung-Ping Su*.
2009 “White Matter Abnormalities
in Schizophrenia Patients with Tardive
Dyskinsia: A Diffusion Tensor Image
Study” Schizophrenia Research, Apr;
109(1-3): 167-181
15. Yawei Cheng, Kun-Hsien
Chou, Jean Decety, I-Yun Chen, Daisy
Hung, Ovid Jyh-Lang Tzeng, Ching-Po
Lin*. 2009 “Sex Differences
in the Neuroanatomy of Human Mirror-Neuron
System: a Voxel-Based Morphometric
Investigation” Neuroscience, Jan;
158(2): 713–720
16. Kuan-Hung Cho,
Chun-Hung Yeh, Jacques-Donald Tournier,
Yi Ping Chao, Jyh-Horng Chen*, Ching-Po
Lin*. 2008 “Evaluation of
the accuracy and angular resolution
of Q-ball imaging” NeuroImage, Aug
1; 42(1): 262-271
17. J-Donald Tournier,
Chun-Hung Yeh, Fernando Calamante,
Kuan-Hung Cho, Alan Connelly, Ching-Po
Lin*. 2008 “Resolving crossing
fibres using constrained spherical
deconvolution: validation using
diffusion weighted imaging phantom
data” NeuroImage, Aug 15; 42(2):
617-625
18. Chun-Hung Yeh,
Kuan-Hung Cho, Hsuan-Cheng Lin,
Jiun-Jie Wang, Ching-Po
Lin*. 2008 “Reduced Encoding
Diffusion Spectrum Imaging Implemented
with a Bi-Gaussian Model” IEEE Transactions
on Medical Imaging, Oct; 27(10):
1415-24
19. Yi-Ping Chao,
Jyh-Horng Chen, Kuan-Hung Cho, Chun-Hung
Yeh, Kun-Hsien Chou,
Ching-Po Lin*. 2008 “A Multiple
Streamline Approach to High Angular
Resolution Diffusion Tractography”
Medical Engineering & Physics,
Oct; 30(8): 989–996
20. Yu-Ming Chuang,
Chih-Yang Liu, Po-Jung Pan, Ching-Po
Lin*. 2008 “Posterior Communicating
Artery Hypoplasia might Contribute
to Acute Ischemic Stroke in the
Absence of Carotid Artery Occlusion”
Journal of Clinical Neuroscience,
Dec; 15(12): 1376-1381
21. Ching-Po
Lin, Wan-Yuo Guo, Kun-Hsien
Chou, Ming-Teh Chen, Min-Hsiung
Chen, Yu-Shu Yen, Yi-Ping Chao,
Donald Ming-Tak Ho. 2008 “Peri-tumoral
Fractional Anisotropy Mapping as
a Prognosticator and Treatment Guidance
of Brain Tumors: A Feasibility Study”
Journal of Medical and Biological
Engineering, Sep; 28 (3): 139-145
22. Yawei Cheng, Po-Lei
Lee, Chia-Yen Yang, Ching-Po
Lin, Jean Decety. 2008 “Gender
Differences in the Mu Rhythm of
the Human Mirror Neuron System”
PLoS ONE, May 7; 3(5): e2113, 1-7
23. Yawei Cheng, Chia-Yen
Yang, Ching-Po
Lin, Po-Lei Lee, Jean Decety.
2008 “The Perception of Pain in
Others Suppresses Somatosensory
Oscillations: A Magnetoencephalography
Study” NeuroImage, May 1; 40(4):
1833-1840
24. Erick Jorge Canales-Rodriguez,
Yasser Aleman-Gomez, Ching-Po
Lin, Yasser Iturria-Medina,
Pedro Valdes-Hernandez, Lester Melie-Garcia.
2008 “A Bayesian framework to identify
principal intravoxel diffusion profiles
based on Diffusion-Weighted MR Imaging”
NeuroImage, Aug 15; 42(2): 750-770
25. Erick Jorge Canales-Rodriguez,
Lester Melie-Garcia, Yasser Iturria-Medina,
Eduardo Martinez-Montes, Yasser
Aleman-Gomez, Ching-Po
Lin. 2008 “Inferring Multiple
Maxima in Intravoxel White Matter
Fiber Distribution” Magnetic Resonance
in Medicine, Sep; 60(3): 616-630
26. Jiun-Jie Wang,
Yu-Chun Lin, Yau-Yau Wai, Hao-Li
Liu, Ching-Po
Lin, Ying-Zu Huang. 2008
“Visualization of the coherence
of the principal diffusion orientation:
an eigenvector-based approach” Magnetic
Resonance in Medicine, 59(4): 764-70
27. Yu-Ming Chuang,
Yuan-Chung Hwang,
Ching-Po Lin*, Chih-Yang
Liu. 2008 “Toward A Further Elucidation:
Role of Vertebral Artery Hypoplasia
in Migraine with Aura” European
Neurology, 59(3-4): 148-151
28. Yawei Cheng, Ching-Po
Lin, Ho-Ling Liu, Yuan-Yu
Hsu, Kun-Eng Lim, Daisy Hung, Jean
Decety. 2007 “Expertise Modulates
Pain Perception in Others” Current
Biology, Oct 9; 17(19): 1708-1713
29. Yu-Ming Chuang,
Chih-Yang Liu, Po-Jung Pan, Ching-Po
Lin*. 2007 “Anterior Cerebral
Artery A1 Segment Hypoplasia May
Contribute to A1 Hypoplasia Syndrome”
European Neurology, Jan 19; 57(4):
208-211
30. Yawei Cheng, Jean
Decety, Ching-Po
Lin, Jen-Chuen Hsieh, Daisy
Hung, Ovid J.L. Tzeng. 2007 “Sex
differences in spinal excitability
during observation of bipedal locomotion”
Neuroreport, 18(9): 887-890
31. Shih-Hwa Chiou,
Chung-Lan Kao, Han-Tso Lin, Wen-Ser
Tseng, Ren-Shyan Liu, Chen-Fun Chung,
Hung-Hai Ku, Ching-Po
Lin, Tai-Tong Wong. 2006
“Monitoring the Growth Effect of
Xenotransplanted Human Medulloblastoma
in Immunocompromised Mice Model
Using In Vitro and Ex Vivo Green
Fluorescent Protein Imaging” Childs
Nervous System, 22: 485-490
32.
Ching-Po Lin, Van J. Wedeen,
Ching Yao, Jyh-Horng Chen, Wen-Yih
I. Tseng. 2003. “Validation of Diffusion
Spectrum Magnetic Resonance Imaging
with Registered Manganese-enhanced
Optic Tracts and Phantom” NeuroImage,
Jul; 19(3): 482-495
33. Ching-Po
Lin, Wen-Yih Isaac Tseng,
Hui-Cheng Cheng, Jyh-Horng Chen.
2001. “Validation of Diffusion Tensor
Magnetic Resonance Axonal Fiber
Imaging with Registered Manganese-enhanced
Optic Tracts” NeuroImage, Nov; 14(5):
1035-1047
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