Address:
155, Li-Nong St. , Sec.2, Peitou, Taipei , Taiwan

Tel: 02-2826-7389
Fax: 02-2827-3123

Email: ibs@ym.edu.tw
http://www.ym.edu.tw/ibs

Associate Prof. Li-Fen Chen, Ph.D

Associate Professor, Institute of Brain Science, National Yang-Ming University
 
Tel: +886-2-2826-7384, Fax: +886-2- 2827-3123
E-mail: lfchen@ym.edu.tw
URL: http://bml.ym.edu.tw
 

Education and professional experience

  • 2011 - now Associate Professor, Institute of Brain Science, National Yang-Ming University
  • 2006 -2011/07Assistant Professor, Institute of Brain Science, National Yang-Ming University
  • 2007 - now Adjunct Assistant Professor, Institute of Biomedical Informatics, National Yang-Ming University.
  • 2005- 2007 Adjunct Assistant Professor, Institute of Health Informatics and Decision Making, National Yang-Ming University.
  • 2004- now Adjunct Associate Research Fellow, Medical Research & Education Department, Taipei Veterans General Hospital
  • 2002 - 2006 Assistant Research Fellow, Center for Neuroscience, National Yang-Ming University
  • 2001- 2002 Postdoctoral Research Fellow, Department of Medicine, National Yang-Ming University
  • 2000- 2001 Postdoctoral Research Fellow, Institute of Information Science, Academia Sinica
  • 2000 Ph.D., Department of Computer Science, National Chiao Tung University
  • 1993 B.S., Department of Computer Science, National Chiao Tung University

Academic honors

  • Good Paper Award, IPPR Conference on Computer Vision, Graphics, and Image Processing, 2004
  • Good Poster Award, NSC Biomedical Engineering Field, 2004
  • Best Paper Award, Journal of Imaging Science and Technology, 2003
  • Good Paper Award, IPPR Conference on Computer Vision, Graphics, and Image Processing, 2000
  • IICM Best Thesis Award, 2000

[Invited speech]

  • Synchronization detection of electromagnetic signals in mood disorders, User Science Institute, Kyushu University, Japan, March 4th, 2008.

Research Interests

  • The Brain Mapping Laboratory aims at the development of pioneer approaches for extracting significant information from brain signals to understand the function and structure of the human brain. Our major goals include:
  • Developing medical image processing techniques for manipulating, morphologically measuring, statistically inferring, and visualizing brain structures of normal subjects and patients.
  • Developing signal processing and electromagnetic mapping technologies for functional imaging of human brains.
  • Imaging cognitive/emotional information processing and constructing the model of emotion regulation in healthy and diseased brains
  • Developing brain informatics and data mining techniques for exploring structure-function association in brain image-signal database.


Publications

(2009 - 2013) (2012 Impact Factor)

[Journal Papers] (*: corresponding author)

  1. Cheng-Ta Li, Li-Fen Chen, Pei-Chi Tu, Shyh-Jen Wang, Mu-Hong Chen, Tung-Ping Su, Jen-Chuen Hsieh (2013) Impaired Prefronto-Thalamic Functional Connectivity as a Key Feature of Treatment-Resistant Depression: a Combined MEG, PET and rTMS Study. PLoS One, 8(8):e70089. [SCI, IF=3.730, RF=0.125 (7/56), MULTIDISCIPLINARY SCIENCES]

  2. Hsiao-Ping Shen, Yong-Sheng Chen, Jen-Chuen Hsieh, Tung-Ping Su, and Li-Fen Chen* (2012) Abnormal Neural Responses to Facial Expression Images in Major Depressive Patients. Journal of Neuroscience and Neuroengineering, 1:90-96. [非SCI]

  3. Hui-Ling Chan, Yong-Sheng Chen*, and Li-Fen Chen (2012) Selection of independent components based on cortical mapping of electromagnetic activity. Journal of Neural Engineering, 9(5):056006. [SCI, IF=3.282, RF=0.1519 (12/79), Engineering, Biomedical]

  4. Peichi Tu, Li-Fen Chen, Jen-Chuen Hsieh, Ya-Mei Bai, Cheng-Ta Li, Tung-Ping Su. (2012) Regional cortical thinning in patients with major depressive disorder: A surface-based morphometry study. Psychiatry Res, 202(3):206-13. [SCI, IF=2.456, RF=0.437 (59/135), Psychiatry]

  5. Tai-Ying Liu, Jen-Chuen Hsieh, Yong-Sheng Chen, Pei-Chi Tu, Tung-Ping Su, and Li-Fen Chen* (2012) Different patterns of abnormal gamma oscillatory activity in unipolar and bipolar disorder patients during an implicit emotion task. Neuropsychologia, 50:1514-1520. [SCI, IF=3.477, RF=0.225 (11/49), Behavioral Sciences]

  6. Jia-Xiu Liu, Yong-Sheng Chen, Jen-Chuen Hsieh, Tung-Ping Su, Tzu-Chen Yeh, and Li-Fen Chen* (2010) Differences in white matter abnormalities between bipolar I and II disorders. Journal of Affective Disorders, 127:309-315. [SCI, IF=3.295, RF=0.251(48/191), Clinical Neurology]

  7. Cheng-Hao Tu, David M. Niddam, Hsiang-Tai Chao, Li-Fen Chen, Yong-Sheng Chen, Yu-Te Wu, Tzu-Chen Yeh, Jiing-Feng Lirng, and Jen-Chuen Hsieh (2010) Brain morphological changes associated with cyclic menstrual pain. Pain, 150(3):462-468. [SCI, IF=5.777, RF=0.035 (1/29), Anesthesiology]

  8. Pin-Shiuan Lee, Yong-Sheng Chen, Jen-Chuen Hsieh, Tung-Ping Su, and Li-Fen Chen* (2010) Distinct neuronal oscillatory responses between patients with bipolar and unipolar disorders: a magnetoencephalographic study. Journal of Affective Disorders, 123:270-275. [SCI, IF=3.295, RF=0.251(48/191), Clinical Neurology]

  9. Jia-Xiu Liu, Yong-Sheng Chen, and Li-Fen Chen* (2010) Fast and accurate registration techniques for affine and nonrigid alignment of MR brain images. Annals of Biomedical Engineering, 38(1):138-157. [SCI, IF=2.575, RF=0.266 (21/79), Engineering, Biomedical]

  10. Jia-Xiu Liu, Yong-Sheng Chen, and Li-Fen Chen* (2009) Accurate and robust extraction of brain regions using a deformable model based on radial basis functions. Journal of Neuroscience Methods, 183(2):255-266. [SCI, IF=2.114, RF=0.587 (44/75), Biochemical Research Methods]

  11. Ren-Jen Hwang, Jen-Chuen Hsieh*, Chi-Hsun Wu, Li-Fen Chen, Tzu-Chen Yeh. (2009) Female menstrual phases modulate human prefrontal asymmetry: a magnetoencephalographic study. Hormones and Behavior, 55:203-209. [SCI, IF=3.735, RF=0.184 (9/49), Behavioral Sciences]

  12. Lynn Y.L. Shih, Li-Fen Chen, Wen-Jui Kuo, Tzu-Chen Yeh, Yu-Te Wu, Ovid J.L. Tzeng, Jen-Chuen Hsieh*. (2009) Sensory acquisition in the cerebellum: An fMRI study of cerebrocerebellar interaction during visual duration discrimination. Cerebellum, 8(2):116-126. [SCI,IF=2.595, RF=0.57 (143/251), NEUROSCIENCES]


[Conference Papers]

  1. Wei-Chi Li, Cheng-Hao Tu, Jen-Chuen Hsieh, Li-Fen Chen (2013) Effect of BDNF Val66Met polymorphism on gray matter volume in primary dysmenorrhea. Poster presented at 43rd Annual Meeting of Society for Neuroscience, San Diego, CA, USA, Nov 9-13, 2013.

  2. Tai-Ying Liu, Yong-Sheng Chen, Tung-Ping Su, Jen-Chuen Hsieh, Li-Fen Chen (2013) Abnormal perceptual responses to sad faces in unipolar and bipolar disorders: an MEG study. Poster presented at 19th Annual Meeting of the Organization for Human Brain Mapping, Seattle, WA, USA, June 16-20, 2013.

  3. Pin-Shiuan Lee, Yong-Sheng Chen, Cheng-Hao Tu, Hsiang-Tai Chao, Jen-Chuen Hsieh, Li-Fen Chen (2013) Impaired functional coupling of resting magnetoencephalography in primary dysmenorrhea. Poster presented at 19th Annual Meeting of the Organization for Human Brain Mapping, Seattle, WA, USA, June 16-20, 2013.

  4. Ian-Ting Chu, Cheng-Hao Tu, Hsiang-Tai Chao, Li-Fen Chen, Jen-Chuen Hsieh (2013) Menstrual pain alters the early perceptual processing of emotional prosody. Poster presented at 19th Annual Meeting of the Organization for Human Brain Mapping, Seattle, WA, USA, June 16-20, 2013.

  5. Ruei-Jyun Hung, Li-Fen Chen, Yong-Sheng Chen (2013) Transient phase-locking of parietal responses to repeated faces: Neuroimage evidence of subliminal mere exposure. Poster presented at 6th Annual Meeting of Social & Affective Neurodcience Society, San Francisco, USA, April 12-13, 2013.

  6. Lin-Chien Lee, Li-Fen Chen, Intan Low, Cheng-Hao Tu, Horng-Der Shen, Hsiang-Tai Chao, Ming-Wei Lin, Jen-Chuen Hsieh. Brain-derived Neurotrophic Factor Val66Met Polymorphism Modulates the Menstrual Pain Related Depressive and Anxious Moods in Primary Dysmenorrhea. Poster presented at 24th Annual Scientific Meeting of Taiwan Pain Society, Taipei, Taiwan, March 9-10, 2013.

  7. Pin-Shiuan Lee, Yong-Sheng Chen, Jen-Chuen Hsieh, Li-Fen Chen (2012) Dysfunction of cross-frequency phase-phase coupling in primary dysmenorrhea: a resting magnetoencephalographic study. Poster presented at 21st Annual Meeting of Organization for Computational Neuroscience, Decatur, Georgia, USA, July 21-26, 2012.

  8. Mei-Ying Wu, Li-Fen Chen, Tung-Ping Su (2012) Effects of Repetitive Transcranial Magnetic Stimulation Treatment on Emotion Regulation in Major Depression: A MEG Study. 國立陽明大學100學年度學術論文研討會(Poster Presentation), Taiwan, June 16, 2012.

  9. Liu T.Y., Chen L.F., Chen Y.S., Hsieh J.C. (2012) Imaging brain dynamics of emotional- perceptual processing by Granger causality analysis: a MEG study. Poster presented at the 18th Annual Meeting of the Organization for Human Brain Mapping, Beijing, China, June 10-14, 2012.

  10. Tung-Ping Su, Li-Fen Chen, Yong-Sheng Chen, Chih-Yu Chan, Pin-Shiuan Lee, Pei-Chi Tu, Jen-Chuen Hsieh (2012) Pattern Classification of Gray Matter Density in Unipolar, Bipolar I, and Bipolar II Patients using Voxel-based Morphometry and Bayesian Classifier. Oral presentation at the 5th Biennial Conference of the International Society for Bipolar Disorders, Istanbul, Turkey, March 14-17, 2012.

  11. Yong-Sheng Chen, Li-Fen Chen, Tzu-Chen Yeh, Jen-Chuen Hsieh, Pin-Shiuan Lee, Kuo-Wei Lee, Yu-Han Shen, Shih-Yen Lin (2011) Pattern Classification of Gray Matter Density in Unipolar, Bipolar I, and Bipolar II Patients using Bayesian Classifier. Poster presented at International Symposium on Clinical Engineering and Medical Informatics, Tainan, Taiwan, Dec. 3, 2011.

  12. Li-Fen Chen, Yong-Sheng Chen, Jen-Chuen Hsieh, Yu-Ying Chou, Chi-Kuang Sun (2011) Dynamic Brain Imaging of Mutual Modulation between Positive Emotion Perception and Cognitive Process (1/3). Poster presented at International Symposium on Clinical Engineering and Medical Informatics, Tainan, Taiwan, Dec. 3, 2011.

  13. Jia-Ping Lin, Yong-Sheng Chen, Li-Fen Chen (2011) Person Identification using Electroencephalographic Signals Evoked by Visual Stimuli. Poster presented at International Conference on Neural Information Processing, Shanghai, China, November 13-17, 2011. Lecture Notes in Computer Science, 7062:684-691.

  14. Chiu-Jung Huang and Li-Fen Chen (2011) Neurophysiological evidence for emotion embodiment. Oral presentation at the 50th Annual Meeting of the Taiwanese Psychological Association, Taichung, Taiwan, Oct. 2011.

  15. Yu-Ying Chou, Chi-Kuang Sun, and Li-Fen Chen (2011) Neural correlates of implicit attitudes towards positive and negative emotions. Oral presentation at the 50th Annual Meeting of the Taiwanese Psychological Association, Taichung, Taiwan, Oct. 2011.

  16. Hui-Ling Chan, Yong-Sheng Chen, Li-Fen Chen (2011) Maximum Multiple-Correlation Beamformer for Estimating Source Connectivities in Electromagnetic Brain Activities. Proceedings of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, Massachusetts, Aug. 30-Sep. 3, 2011, pp. 5024-5027.

  17. Pin-Shiuan Lee, Li-Fen Chen, Yong-Sheng Chen, Tung-Ping Su, Jen-Chuen Hsieh (2011) Discriminant maps of cortical activity for classification of affective disorders. Poster presented at the 17th Annual Meeting of the Organization on Human Brain Mapping in Quebec City, Canada, June 26-30, 2011.

  18. Tai-Ying Liu, Li-Fen Chen, Yong-Sheng Chen, Jen-Chuen Hsieh (2010) Distinct gamma oscillatory responses to different facial images during early visual processing: an MEG study. Poster presented at Annual Symposium of Biomedical Engineering, Kaohsiung, Taiwan, Dec, 2010.

  19. Tzu-han Hu and Li-Fen Chen, Tung-Ping Su, Jen-Chuen Hsieh (2010) Pattern classification of resting oscillatory neuromagnetic activity among patients with mood disorder. Poster presented at 2010 Annual Symposium of Biomedical Engineering, Kaohsiung, Taiwan, Dec, 2010.

  20. Chi-Kuang Sun, Yu-Ying Chou, Li-Fen Chen (2010) Neural correlates of implicit attitudes towards positive and negative emotions. Poster presented at 2010?Social and?Affective Neuroscience?Conference, Chicago, IL, Oct, 2010.

  21. Hsin-Fang Lee, Li-Fen Chen, Chang-Hung Lin, Yong-Sheng Chen (2010) Comparison of subjective Epworth Sleepiness Scale with objective polysomnographic evidences. Poster presented at the 20th Congress of the European Sleep Research Society, Lisbon, Portugal, Sep 14-18, 2010.

  22. Chang-Hung Lin, Yong-Sheng Chen, Yu-Shiuan Yen, Li-Fen Chen (2010) High correlation between sleep disorders and driving safety in Taiwan. Poster presented at the 20th Congress of the European Sleep Research Society, Lisbon, Portugal, Sep 14-18, 2010.

  23. Hsu - Ping Tuan, Tung- Ping Su, Jen - Chuen Hsieh, Li - Fen Chen (2010) A 3-Month Follow-Up Magnetoencephalographic Study of Repetitive Transcranial Magnetic Stimulation in Major Depression. Poster presented at 16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona, Spain, June, 2010.

  24. Yu-Chen Lan, Li-Fen Chen, and Jen-Chuen Hsieh (2010) Film-induced positive emotions modulate pain perception and pain related emotions. Poster presented at 16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona, Spain, June, 2010.

  25. Chen L.F., Liu T.Y., Chen Y.S., Hsieh J.C. (2010) Different gamma oscillation patterns for angry facial expressions in MDD and NC during early visual processing: an MEG study. The 16th Annual Meeting of the Organization for Human Brain Mapping 2010, Barcelona, Spain, June 6-10, 2010.

  26. Liang-Wei Chen, Yong-Sheng Chen, and Li-Fen Chen (2009) Three-choice brain-computer interface system through classification and voting of temporal features. Proceedings of 2009 CACS International Automatic Control Conference, Taipei, Taiwan, Nov. 2009.

  27. Tai-Ying Liu, Li-Fen Chen, Yong-Sheng Chen, Jen-Chuen Hsieh, Tung-Ping Su (2009) Different patterns of abnormal gamma oscillations in bipolar and unipolar disorder patients. Poster presented at the 1st Meeting of the Asian College of Neuropsychopharmacology (AsCNP), Kyoto, Japan, Nov. 13-14, 2009.

  28. Yong-Sheng Chen, Li-Fen Chen, Tung-Ping Su, Jen-Chuen Hsieh, Kui-Han Lin (2009) Structural differences of gray matter between patients with unipolar and bipolar disorders assessed by voxel-based morphometric analysis. Poster presented at the 9th World Congress of Biological Psychiatry, Paris, France, Jun. 28-Jul. 2, 2009.

  29. Yu-Shiuan Yen, Li-Fen Chen, Yong-Sheng Chen, Jen-Chuen Hsieh (2009) Gender effects on neuronal dynamics underlying emotion regulation in the limbic and prefrontal cortex. Poster presented at the 15th Annual Meeting of the Organization for Human Brain Mapping, San Francisco, CA, Jun. 18-23, 2009.

  30. I-Tzu Chen, Yong-Sheng Chen, Li-Fen Chen (2009) Beamformer-based spatiotemporal imaging of correlated brain activities. Proceedings of the Ninth IEEE International Conference on Bioinformatics and Bioengineering, Taichung, Taiwan, Jun. 2009, pp. 431-434.

  31. Yu-Hsun Lee, Yong-Sheng Chen, Li-Fen Chen (2009) Automated sleep staging using single EEG channel for REM sleep deprivation. Proceedings of the Ninth IEEE International Conference on Bioinformatics and Bioengineering, Taichung, Taiwan, Jun. 2009, pp. 439-442.

  32. Huiling Chan, Yong-Sheng Chen, Li-Fen Chen, Tzu-Hua Chen, I-Tzu Chen (2009) Lead Field Space Projection for Spatiotemporal Imaging of Independent Brain Activities. Proceedings of the 6th International Symposium on Neural Networks, Wuhan during May 26-29, 2009.

[Domestic Patent]

  1. Jen-Chuen Hsieh, Tzu-Chen Yeh, Yu-Te Wu, Po-Lei Lee, Yong-Sheng Chen, Li-Fen Chen. “System andMethod for Classification of EEG Signal and EEG-driven Human-computer Interface,”R.O.C.274269, 2007.02.21~2022.12.01.
    “腦波訊號分類方法及腦波訊號驅動之人機控制系統及方法,”

  2. Jen-Chuen Hsieh, Tzu-Chen Yeh, Yu-Te Wu, Po-Lei Lee, Yong-Sheng Chen, Li-Fen Chen “視覺驅動控制系統及其控制方法,” R.O.C. 204754, 2004.06.11

[International Patent]

  • Jen-Chuen Hsieh, Tzu-Chen Yeh, Yu-Te Wu, Po-Lei Lee, Li-Fen Chen (2008) Method and Apparatus for Visual derive control. US Patent No.7338171 B2, 2008/03/04~2022/12/31.